Tissue-derived macromolecules and markers of inflammation in serum in early rheumatoid arthritis: relationship to development of joint destruction in hands and feet.
Tissue-derived macromolecules and markers of inflammation in serum in early rheumatoid arthritis: relationship to development of joint destruction in hands and feet.
复制标题
早期类风湿性关节炎血清中组织源性大分子和炎症标志物：与手足关节破坏发展的关系。
DOI：
10.1093/rheumatology/36.11.1161
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
T. Saxne
中科院分区：
文献类型：
--
作者：
E. Fex;K. Eberhardt;T. Saxne
我们先前已经证明，类风湿性关节炎(RA)患者早期血清软骨低聚基质蛋白(COMP)浓度升高，这些患者随后发展为晚期大关节破坏。先前的研究也提示了血清透明质酸(HA)浓度对关节损害的预测价值。相比之下，血清骨涎蛋白(BSP)浓度并不能用于识别进行性大关节破坏的患者。在本研究中，我们验证了一种假说，即血清中这些组织衍生标记物的浓度对类风湿关节炎的预后有价值，以发展放射学可检测到的手部和足部关节损伤。对62例RA患者发病后1年内的血清COMP、HA和BSP浓度进行了测定，并与5年后这些关节的放射学可检测损伤的发展有关。包涵体中COMP和BSP的血清浓度均不能预测5年后手和脚的关节损伤，并且这些蛋白的浓度在5年内没有变化。然而，包裹体时的血清HA浓度与5年随访时的放射学评分相关(r=0.425，P<；0.01)，但在这方面并不能比包裹体时的血沉或C反应蛋白水平更好地预测这一点。因此，在这项研究中，三种被研究的组织源性大分子的血清浓度对于识别容易发生小关节破坏的患者没有用处。
We have previously shown that serum concentrations of cartilage oligomeric matrix protein (COMP) are increased early in rheumatoid arthritis (RA) patients who subsequently develop advanced large-joint destruction. A prognostic value for joint damage of serum concentrations of hyaluronan (HA) is also suggested by previous studies. In contrast, serum concentrations of bone sialoprotein (BSP) have not been useful for identifying patients with progressive large-joint destruction. In the present study, we have examined the hypothesis that serum concentrations of these tissue-derived markers are of prognostic value in RA for the development of radiographically detectable joint damage in hands and feet. Serum concentrations of COMP, HA and BSP were quantified in samples obtained from 62 patients within the first year after onset of RA and were related to the development of radiographically detectable damage in these joints after 5 yr. Neither the serum concentrations of COMP nor of BSP at inclusion predicted joint damage in hands and feet after 5 yr, and the concentration of these proteins did not change over the 5 yr period. However, the serum concentration of HA at inclusion correlated with the radiographic score at the 5 yr follow-up (r = 0.425, P < 0.01), but was not a better predictor in this respect than the erythrocyte sedimentation rate or C-reactive protein levels at inclusion. Thus, serum concentrations of the three studied tissue-derived macromolecules were in this study not useful for identifying patients prone to small-joint destruction.