Periodontal disease as a risk factor for pre-eclampsia: A case control study
Periodontal disease as a risk factor for pre-eclampsia: A case control study
复制标题
DOI：
10.1111/j.1479-828x.2004.00323.x
复制
发表时间：
2004-12-01
影响因子：
1.7
通讯作者：
Yagiz, H
中科院分区：
文献类型：
--
作者：
Canakci, V;Canakci, CF;Yagiz, H
目的：探讨牙周病与子痫前期的关系，同时控制子痫前期已知的危险因素。方法：对41例子痫前期妇女和41例血压正常的健康孕妇进行配对病例-对照研究。子痫前期妇女和对照组分别根据年龄、妊娠、胎次、吸烟和产前护理进行匹配。在分娩前48小时内测定除第三磨牙外的所有牙面牙齿数量、修复体数量和龋坏情况，以及临床牙周参数。自变量与子痫前期的关系采用基于受试者的条件多元逻辑回归分析进行评估。结果：两组患者斑块部位的平均百分比差异无统计学意义。子痫前期患者的平均探查深度（PD）和平均临床附着水平（CAL）显著高于正常血压患者（P < 0.01）。子痫前期患者探测出血部位（BOP）的比例（P < 0.05）、PD >= 4 mm、CAL >= 3 mm的部位数量显著高于血压正常者（P < 0.01）。条件多元logistic回归分析显示牙周病和甘油三酯水平与先兆子痫有显著相关性。其他独立变量（母体体重和血清总胆固醇水平）似乎与先兆子痫无关。条件多元logistic回归结果显示，子痫前期患者患牙周病的可能性是正常患者的3.47倍（95% CI = 1.07-11.95）。结论：目前的研究表明，怀孕期间的母亲牙周病与子痫前期发展的风险增加有关。牙周病参数在子痫前期组较高的发生率提示牙周病可能在子痫前期的发展中起作用。牙周炎和子痫前期的本质都是多因素的，当涉及到牙周病引起子痫前期时应谨慎。
Objective: To investigate the association between periodontal disease and pre-eclampsia, while controlling known risk factors for pre-eclampsia.Methods: A matched case-control study was carried out on 41 pre-eclamptic women and 41 normotensive, healthy, pregnant, control women. The pre-eclamptic women and controls were individually matched for age, gravidity, parity, smoking and prenatal care. The number of teeth and the number of restorations and decay on all tooth surfaces, and clinical periodontal parameters, excluding third molars were determined within 48 h before delivery. The relation of independent variables to pre-eclampsia was assessed using conditional multiple logistic regression analysis on subject-based data.Results: There were no statistically significant differences in mean percentages of sites with plaque between groups. The mean probing depth (PD) and mean clinical attachment level (CAL) for pre-eclamptic patients were significantly greater compared to those of normotensive patients (P < 0.01). The percentage of sites exhibiting bleeding on probing (BOP) (P < 0.05), the number of sites with PD >= 4 mm and with CAL >= 3 mm was significantly higher among pre-eclamptic patients than those with normotensive patients (P < 0.01). Conditional multiple logistic regression analysis indicated that periodontal disease and triglycerides level were significantly associated with pre-eclampsia. Other independent variables (maternal body weight and serum total cholesterol level) did not appear to be associated with pre-eclampsia. Conditional multiple logistic regression results showed that pre-eclamptic patients were 3.47 (95% CI = 1.07-11.95) times more likely to have periodontal disease than normotensive patients.Conclusion: The present study shows that maternal periodontal disease during pregnancy is associated with an increased risk for the development of pre-eclampsia. The higher incidence of periodontal disease parameters in pre-eclamptic group would suggest a possible role for periodontal disease in the development of pre-eclampsia. The nature both of periodontitis and pre-eclampsia is multifactorial, and caution should be exercised when implicating periodontal disease in causation of pre-eclampsia.