Surface treatment of injectable strontium-containing bioactive bone cement for vertebroplasty
Surface treatment of injectable strontium-containing bioactive bone cement for vertebroplasty
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DOI：
10.1002/jbm.b.20041
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发表时间：
2004-04-15
影响因子：
3.4
通讯作者：
Yao, KD
中科院分区：
文献类型：
--
作者：
Zhao, F;Lu, WW;Yao, KD
以含锶羟基磷灰石（Sr-HA）为无机填料，双酚A二缩水甘油醚二甲基丙烯酸酯（Bis-GMA）为有机基质，制备了一种新型可注射生物活性骨水泥（SrHAC），用于椎体成形术。在这项研究中，Sr-HA粉末表面处理与甲基丙烯酸甲酯（MMA），以提高两相的界面结合。在表面处理后，根据ISO 5833在37 ℃的蒸馏水中浸泡24小时后测试的压缩强度和杨氏模量分别增加了68.65%（P < .001）和31.02%（p < .001）。生物活性骨水泥的抗弯强度和抗弯刚度分别提高了54.44%（p < .001）和83.90%（p < .001）。此外，水泥的处理性能也得到了提高。体外生物力学测试表明，经表面处理的SrHAC骨水泥固定后，骨折脊柱的刚度恢复到完整状态的82.5%（P <0.01）。与骨折的脊柱相比，使用原始和MMA处理的SrHAC骨水泥的脊柱的失效载荷提高了14.25%（P <0.05）和46.91%（P <0.05）。这项研究的结果表明，MMA处理的SrHAC具有更好的骨科应用的机械效果。(C)2004 Wiley Periodicals，Inc.
A novel injectable bioactive bone-bonding cement (SrHAC) composed of strontium-containing hydroxyapatite (Sr-HA) as the inorganic filler and bisphenol A diglycidylether dimethacrylate (Bis-GMA) as the organic matrix for vertebroplasty was developed previously. In this study, the Sr-HA powders were surface treated with methyl methacrylate (MMA) to improve the interface integration of the two phases. After surface treatment, the compression strength and Young's modulus, which were tested after immersion in distilled water at 37 degreesC for 24 h according to ISO 5833, were increased by 68.65 % (P < .001) and 31.02% (p < .001), respectively. The bending strength and bending stiffness of the bioactive bone cement were significantly improved by 54.44% (p < .001) and 83.90% (p < .001). In addition, the handling property of the cement was also enhanced. In vitro biomechanical testing showed that the stiffness of the fractured spine recovered to 82.5% (P < .01) of the intact condition after cementation with surface-treated SrHAC. The failure load of the spine cemented with original and MMA-treated SrHAC improved by 14.25% (P < .05) and 46.91% (p < .05) in comparison with the fractured spines. Results from this study revealed that the MMA-treated SrHAC has a better mechanical effect for orthopedic applications. (C) 2004 Wiley Periodicals, Inc.