Adherence to host extracellular matrix and serum components by Enterococcus faecium isolates of diverse origin.
Adherence to host extracellular matrix and serum components by Enterococcus faecium isolates of diverse origin.
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不同来源的屎肠球菌分离株对宿主细胞外基质和血清成分的粘附。
DOI：
10.1111/j.1574-6968.2009.01806.x
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发表时间：
2009
影响因子：
2.1
通讯作者：
Murray,BarbaraE
中科院分区：
文献类型：
--
作者：
Zhao,Meng;Sillanpää,Jouko;Nallapareddy,SreedharR;Murray,BarbaraE
屎肠球菌在过去的二十年中已成为医院感染的重要原因。我们最近证明I型胶原蛋白（CI）是some E的常见粘附靶点。faeciumisolates和一个显着的相关性之间存在acm介导的CI坚持和临床起源。在这里，我们评估了60个不同的。faeciumisolates的粘附多达15个固定的主机细胞外基质和血清成分。粘附表型最常观察到纤连蛋白（Fn）（20%的60株），纤维蛋白原（17%）和层粘连蛋白（Ln）（13%），而只有一个或两个分离株粘附V型胶原蛋白（CV），转铁蛋白或乳铁蛋白，没有其他主机组件测试。对Fn和Ln的粘附几乎仅限于临床分离株，特别是心内膜炎富集的医院基因组克隆复合物17（CC17）。因此，除了CI之外，粘附Fn和Ln的能力可能有助于E的出现和适应。粪菌，特别是CC17，作为医院病原体。
Enterococcus faeciumhas emerged as an important cause of nosocomial infections over the last two decades. We recently demonstrated collagen type I (CI) as a common adherence target for someE. faeciumisolates and a significant correlation was found to exist betweenacm-mediated CI adherence and clinical origin. Here, we evaluated 60 diverseE. faeciumisolates for their adherence to up to 15 immobilized host extracellular matrix and serum components. Adherence phenotypes were most commonly observed to fibronectin (Fn) (20% of the 60 isolates), fibrinogen (17%) and laminin (Ln) (13%), while only one or two of the isolates adhered to collagen type V (CV), transferrin or lactoferrin and none to the other host components tested. Adherence to Fn and Ln was almost exclusively restricted to clinical isolates, especially the endocarditis-enriched nosocomial genogroup clonal complex 17 (CC17). Thus, the ability to adhere to Fn and Ln, in addition to CI, may have contributed to the emergence and adaptation ofE. faecium, in particular CC17, as a nosocomial pathogen.