Nephrogenic systemic fibrosis: a review and exploration of the role of gadolinium.
Nephrogenic systemic fibrosis: a review and exploration of the role of gadolinium.
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DOI：
10.1016/j.yadr.2007.07.002
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Cowper, Shawn E
中科院分区：
文献类型：
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作者：
Cowper, Shawn E
NSF是一种新兴的疾病。迄今为止，大量的研究工作导致了一种意想不到的疑似含钆造影剂。目前正在进行大量的额外工作，以制定关于在肾病患者人群中使用这些药物的具体建议。近期研究的目标包括：（1）确定肾脏疾病患者发生NSF所必须满足的风险因素和条件;（2）造影剂的特征，这些特征或多或少可能诱发NSF;（3）制定预防或治疗策略，以减少NSF的总体发展和严重程度。调查过程已经产生了新的洞察力的功能（和故障）的CF在NSF的设置。随着CF越来越多地涉及其他器官特异性和全身性纤维化疾病，我们可以期待在相关疾病的研究中也会看到重大进展。
NSF is a new and emerging disease. Significant investigative work to date has led to an unexpected suspect-gadolinium-containing contrast agents. Considerable additional work is now underway to formulate specific recommendations about the use of these agents in the population of patients who have renal disease. Goals on the immediate research horizon include (1) the identification of risk factors and conditions that must be met to permit the development of NSF in patients who have renal disease, (2) the characteristics of contrast agents that make them more or less likely to induce NSF, and (3) the development of prophylactic or treatment strategies that can reduce the overall development and severity of NSF. The investigative process has already yielded new insight into the functions (and malfunctions) of the CF in the setting of NSF. As the CF is being increasingly implicated in other organ-specific and systemic fibrosing disorders, we can expect to see significant developments in the studies of allied disorders as well.