Acute Leukemias of Ambiguous Lineage: Clarification on Lineage Specificity.
Acute Leukemias of Ambiguous Lineage: Clarification on Lineage Specificity.
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DOI：
10.1016/j.path.2019.03.008
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发表时间：
2019-09-01
影响因子：
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通讯作者：
Weinberg, Olga K
中科院分区：
文献类型：
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作者：
Kurzer, Jason H;Weinberg, Olga K
谱系不明确的急性白血病（ALAL）包括急性未分化白血病和混合表型急性白血病（MPAL）。本文概述了 ALAL 的诊断，并重点介绍了当前含有多个谱系相关标记的原始细胞的谱系分配标准的数据。此外，对目前已知的分子数据进行了回顾，结果表明 MPAL 相关基因突变、甲基化特征和表达谱是急性髓系白血病和急性淋巴细胞白血病中所见的混合体。最后，对 MPAL 的预后和目前的治疗进行了简要讨论。
Acute leukemias of ambiguous lineage (ALAL) include acute undifferentiated leukemia and mixed-phenotype acute leukemia (MPAL). This article provides an overview of the diagnosis of ALAL and focuses on the data accounting for the current lineage-assignment criteria for blasts harboring more than one lineage-associated marker. In addition, the currently known molecular data are reviewed, which show that MPAL-associated gene mutations, methylation signatures, and expression profiles are a mixture of those seen in both acute myeloid leukemia and acute lymphoblastic leukemia. Finally, the prognosis and current treatments of MPAL are briefly discussed.