New phenylpropanoids from Bulbophyllum retusiusculum
New phenylpropanoids from Bulbophyllum retusiusculum
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DOI：
10.1007/s12272-018-1067-6
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发表时间：
2018-11-01
影响因子：
6.7
通讯作者：
Ding, Zhong-Tao
中科院分区：
文献类型：
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作者：
Fang, Yun-Shan;Yang, Ming-Hui;Ding, Zhong-Tao
两个新苯丙素类化合物retusiusine A（1）和B（2）及一对新苯丙素对映体（+/-）-retusiusine C（3a和3b），以及八种已知化合物，二氢松柏基二氢-对-香豆酸酯（4），3-（4-羟基苯基）丙酸酯（5），3-（4-羟基苯基）-丙酸（6）、二氢阿魏酸（7）、3-（4-羟基苯基）-丙酸甲酯（7）、从石豆兰（Bulbophyllum retusiusculum）的块茎中分离得到4-（4-甲氧基苯基）丙酸酯（8）、3-（3，4-二甲氧基苯基）-2-丙烯醛（9）、反式对香豆酸（10）和二氢松柏醇（11）。通过计算新化合物的电子圆二色性（ECD）、光谱和比旋光度，并将计算值与实验值进行比较，确定了新化合物的绝对构型。化合物2对白色念珠菌具有较强的抑菌活性（16 g/mL）。化合物3对枯草芽孢杆菌（Bacillus subtilis）表现出中等的抗菌活性（64 g/mL）。
Two new phenylpropanoids, retusiusines A (1) and B (2), and a pair of new phenylpropyl enantiomers, (+/-)-retusiusine C (3a and 3b), together with eight known compounds, dihydroconiferyl dihydro-p-coumarate (4), methyl 3-(4-hydroxyphenyl) propionate (5), 3-(4-hydroxyphenyl)-propanoic acid (6), dihydroferulic acid (7), methyl 3-(4-methoxyphenyl) propionate (8), 3-(3,4-dimethoxyphenyl)-2-propenal (9), trans-p-coumaric acid (10) and dihydroconiferyl alcohol (11), were isolated from the tubers of Bulbophyllum retusiusculum. The absolute configurations of the new compounds were determined by calculating their electronic circular dichroism (ECD), spectra and specific optical rotations and comparing the calculated values with the experimental data. Compound 2 exhibited potent antifungal activity against Candida albicans (16g/mL). Compound 3 showed moderate antibacterial activity against Bacillus subtilis (64g/mL).