Urinary bisphenol A, phthalate metabolites, and obesity: do gender and menopausal status matter?
Urinary bisphenol A, phthalate metabolites, and obesity: do gender and menopausal status matter?
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DOI：
10.1007/s11356-020-09570-x
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发表时间：
2020-06-16
影响因子：
5.8
通讯作者：
Jee, Sun Ha
中科院分区：
文献类型：
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作者：
Lim, Jung-eun;Choi, BongKyoo;Jee, Sun Ha
先前关于尿双酚A（BPA）、邻苯二甲酸酯代谢物和肥胖风险的研究显示了不一致的结果。月经状况是影响女性激素分泌变化的主要因素之一。在这项研究中，我们研究了尿BPA和邻苯二甲酸酯代谢物水平是否与肥胖有关，以及在韩国成年人群样本中，这种关联是否因性别和绝经状态而异。我们从2015年到2016年在韩国医疗研究所的三个分支机构（汝矣岛，江南和光化门）招募了参与者，这是一个全国性的健康检查中心。通过高效液相色谱-串联质谱法（Agilent 6490 Triple Quad LC-MS/MS; Agilent Technologies，CA，USA）测量尿BPA水平。采用超高效液相色谱-串联质谱法（TSQ Quantum Access Mass; Thermo Fisher Scientific，MA，USA）分析尿液中的6种邻苯二甲酸酯代谢物。体重指数>= 25 kg/m2者为一般肥胖组。男性腰围≥ 90 cm，女性腰围≥ 85 cm为腹型肥胖组。年龄、性别、饮酒、吸烟和运动被纳入多变量logistic回归模型。在总共702名参与者中，211名参与者被归类为一般肥胖组，131名参与者被归类为腹部肥胖组。尿邻苯二甲酸酯代谢物水平与男性和女性的全身和腹部肥胖无关。然而，在女性中，尿BPA浓度与腹型肥胖呈正相关（OR = 1.50，95%CI 1.00-2.26）。绝经后妇女的相关性较强（OR = 2.23，1.01-4.92），而绝经前妇女的相关性较弱（OR = 1.31，0.78-2.20）。在这项研究中，尿BPA浓度与女性，特别是绝经后女性的腹部肥胖有关。未来的研究在调查尿BPA、邻苯二甲酸酯代谢物水平和肥胖之间的关系时，应考虑性别和绝经状态。
Previous studies of urinary bisphenol A (BPA), phthalate metabolites, and obesity risk have shown inconsistent results. Menopausal status is one of the main factors that affect hormone secretion change in women. In this study, we examined whether urinary BPA and phthalate metabolite levels are associated with obesity and whether the associations differ by sex and menopausal status in a sample of Korean adult populations. We recruited participants at three branches (Yeouido, Gangnam, and Gwanghwamun) of the Korea Medical Institute, a nationwide health check-up center, from 2015 to 2016. Urinary BPA level was measured by high-performance liquid chromatography-tandem mass spectrometry (Agilent 6490 Triple Quad LC-MS/MS; Agilent Technologies, CA, USA). Urinary six phthalate metabolites were analyzed with ultra-high-performance liquid chromatography-tandem mass spectrometry (TSQ Quantum Access Mass; Thermo Fisher Scientific, MA, USA). Participants with body mass index >= 25 kg/m(2)were defined as general obesity group. Men with waist circumference (WC) >= 90 cm and women with WC >= 85 cm were defined as abdominal obesity group. Age, sex, alcohol intake, smoking, and exercise were considered in multivariate logistic regression models. Among the total of 702 participants, 211 participants were classified into the general obesity group, and 131 participants were classified into the abdominal obesity group. Urinary phthalate metabolite levels were not associated with general and abdominal obesity in men and women. However, in women, urinary BPA concentration was positively associated with abdominal obesity (OR = 1.50, 95% CI 1.00-2.26). Also, the association was stronger in postmenopausal women (OR = 2.23, 1.01-4.92), while it was weak in premenopausal women (OR = 1.31, 0.78-2.20). In this study, urinary BPA concentration was associated with abdominal obesity in women, especially postmenopausal women. Future studies should consider sex and menopausal status when investigating associations between urinary BPA, phthalate metabolites levels, and obesity.