Scaling Behavior in Soft Materials Revealed by Lipid ACYL Chain Order
Scaling Behavior in Soft Materials Revealed by Lipid ACYL Chain Order
复制标题
脂质 ACYL 链序揭示软材料的结垢行为
DOI：
10.1016/j.bpj.2019.11.1352
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发表时间：
2020
影响因子：
3.4
通讯作者：
Petrache, Horia I.
中科院分区：
文献类型：
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作者：
Ramkumar, Abhinav;Leng, Xiaoling;Brown, Michael F.;Petrache, Horia I.
标度或标度律是自然系统的一般性质。缩放的一个简单示例是给定几何形状的表面积和体积之间的关系。特别地，脂质双层是其中结垢性质表现为酰基链长度的函数的物理系统。测量，如氘代脂质的2 H NMR光谱，在相当长的一段时间内暗示了普遍的标度行为，尽管精确的标度不能从测量的序参数立即获得[1]。在这里，我们使用统计力学和分子动力学模拟，以获得热力学参数，直接揭示了一个普遍的行为，从缩放作为酰基链长度和温度的函数。特别是，利用平均扭矩模型[2]将膜有序参数与取向熵联系起来，从而深入了解脂质链所经历的对齐场。给出了统计结果以及它们与生物膜功能的可能相关性[3]。
Scaling, or scaling laws are general properties of natural systems. One simple example of scaling is the relationship between the surface area and the volume of a given geometric shape. Lipid bilayers, in particular are physical systems in which scaling properties are manifested as a function of acyl chain length. Measurement such as 2 H NMR spectroscopy of deuterated lipids had for quite some time hinted at a universal scaling behavior although the exact scaling is not immediately accessible from the measured order parameters [1]. Here we use statistical mechanics and molecular dynamics simulations to obtain thermodynamic parameters that directly reveal a universal behavior that arises from scaling as a function of acyl chain length and temperature. In particular, the mean-torque model [2] is utilized to relate membrane order parameters to orientational entropies, which gave insight into the alignment field experienced by lipid chains. Statistical results are presented as well as their possible relevance to the function [3] of biological membranes.