Motor and non-motor symptoms in blepharospasm: clinical and pathophysiological implications
Motor and non-motor symptoms in blepharospasm: clinical and pathophysiological implications
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DOI：
10.1007/s00415-019-09484-w
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发表时间：
2019-11-01
影响因子：
6
通讯作者：
Berardelli, Alfredo
中科院分区：
文献类型：
--
作者：
Ferrazzano, Gina;Berardelli, Isabella;Berardelli, Alfredo
简介 眼睑痉挛患者除了眼轮匝肌不自主收缩外，还存在非运动症状（精神、睡眠、认知和眼部症状）。在本文中，我们研究了眼睑痉挛患者非运动症状与运动症状的关系以及非运动症状的总负担。将结果与年龄和性别匹配的健康对照进行比较。方法 我们招募了 60 名眼睑痉挛患者和 40 名年龄匹配的健康对照者。在所有患者中，使用眼睑痉挛严重程度评定量表对眼睑痉挛的严重程度进行临床评估。所有参与者都接受了精神、睡眠、认知和眼部症状评估。我们研究了运动、非运动症状与患者的临床和人口特征之间的相关性。结果 眼睑痉挛患者出现精神、睡眠、认知障碍和眼部症状的频率高于健康对照者。大多数患者同时存在非运动症状，并且非运动症状与运动症状之间没有相关性。非运动症状的总负担与眼睑痉挛的运动症状和人口特征无关。结论 非运动症状与运动特征无关，可能属于眼睑痉挛的临床谱。非运动症状的存在可能反映了眼睑痉挛的复杂网络障碍。
Introduction Patients with blepharospasm in addition to involuntary contraction of the orbicularis oculi muscle also have non-motor symptoms (psychiatric, sleep, cognitive, and ocular). In this paper, we investigated the relationship of non-motor with motor symptoms and the total burden of non-motor symptoms in patients with blepharospasm. Results were compared with those of age- and sex-matched healthy controls. Methods We enrolled 60 patients with blepharospasm and 40 age-matched healthy controls. In all patients, the severity of blepharospasm was assessed clinically with the Blepharospasm Severity Rating Scale. All the participants underwent a psychiatric, sleep, cognitive, and ocular symptom evaluation. We investigated the correlations between motor, non-motor symptoms, and patients' clinical and demographic features. Results The frequency of psychiatric, sleep, and cognitive disorders and ocular symptoms was higher in blepharospasm patients than in healthy controls. Non-motor symptoms coexisted in the majority of patients and there was no correlation between non-motor and motor symptoms. The total burden of non-motor symptoms did not associate with motor symptoms and demographic features in blepharospasm. Conclusions Non-motor symptoms are independent of motor features and likely belong to the clinical spectrum of blepharospasm. The presence of non-motor symptoms possibly reflects a complex network disorder of blepharospasm.