Nanohoneycomb Surface-Enhanced Raman Spectroscopy-Active Chip for the Determination of Biomarkers of Hepatocellular Carcinoma
Nanohoneycomb Surface-Enhanced Raman Spectroscopy-Active Chip for the Determination of Biomarkers of Hepatocellular Carcinoma
复制标题
纳米蜂窝表面增强拉曼光谱活性芯片用于测定肝细胞癌生物标志物
DOI：
10.1021/acsami.9b16288
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发表时间：
2019-11-27
影响因子：
9.5
通讯作者：
Zhang, Xuefeng
中科院分区：
文献类型：
--
作者：
Zhu, Aonan;Zhao, Xiaoyu;Zhang, Xuefeng
Overexpression of the Lens culinaris agglutininreactive fraction of alpha-fetoprotein (AFP-L3) is an essential biomarker for early diagnosis of hepatocellular carcinoma (HCC). In this study, we designed a new surface-enhanced Raman spectroscopy active chip for the detection of AFP with high sensitivity and excellent repeatability. This chip was composed of a honeycomb gold nanostructure array with strong electromagnetic field coupling due to the special cavity geometric characteristics of the honeycomb structure. The honeycomb structure exhibited extraordinary performance for the specific detection of AFP in the range of 0.003-3 ng/mL and also determined the proportion of AFP-L3 with a high degree of accuracy, which has shown great potential for application in the clinical diagnosis of HCC.
