INVIVO STUDIES OF MEDIATOR RELEASE IN COLD URTICARIA AND CHOLINERGIC URTICARIA
INVIVO STUDIES OF MEDIATOR RELEASE IN COLD URTICARIA AND CHOLINERGIC URTICARIA
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DOI：
10.1016/0091-6749(75)90078-0
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发表时间：
1975-01-01
影响因子：
14.2
通讯作者：
BEAVEN, MA
中科院分区：
文献类型：
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作者：
KAPLAN, AP;GRAY, L;BEAVEN, MA
6例冷荨麻疹患者血浆组胺水平升高后，冷挑战，将1只手在冰水中4分钟。一个单一的病人在手术过程中变得肿胀，并有一个水平的260 ng/ml组胺从他的手的静脉流出物。未观察到血浆5-羟色胺或缓激肽升高。2例胆碱能性荨麻疹患者在剧烈运动10分钟期间和之后血浆组胺水平升高;这些患者还对振动诱导的血管性水肿进行了阳性检测。一例胆碱能性荨麻疹患者血清素基线水平升高，运动期间和运动后血清素水平升高，但血浆组胺或缓激肽未升高。组胺可能是冷性荨麻疹的主要介质和低血压。组胺也似乎释放一致的发展与荨麻疹在一些患者的胆碱能性荨麻疹，而血清素水平升高，在一个单一的非典型患者表明，一个亚群的胆碱能性荨麻疹患者具有不同的发病机制。
Six patients with cold urticaria had elevated plasma histamine levels after cold challenge by placing 1 hand in ice water for 4 min. A single patient became hypotensive during the procedure and had a level of 260 ng/ml histamine in the venous effluent from his hand. No elevation of plasma serotonin or bradykinin was observed. Two patients with cholinergic urticaria possessed elevated plasma histamine levels during and after vigorous exercise for 10 min; these patients also gave a positive test for vibration-induced angioedema. A single patient with cholinergic urticaria possessed elevated baseline serotonin levels and elevated levels during and after exercise but no elevation of plasma histamine or bradykinin. Histamine is probably the major mediator of urticaria and hypotension in cold urticaria. Histamine also appears to be released coincident with the development of urticaria in some patients with cholinergic urticaria, while elevated serotonin levels in a single atypical patient suggest that a subpopulation of patients with cholinergic urticaria possess a different pathogenesis.