Characterization of a new strain of HHV-6 (HHV-6SF) recovered from the saliva of an HIV-infected individual.
Characterization of a new strain of HHV-6 (HHV-6SF) recovered from the saliva of an HIV-infected individual.
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从 HIV 感染者唾液中回收的 HHV-6 新毒株 (HHV-6SF) 的特征。
DOI：
10.1016/0042-6822(90)90384-4
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发表时间：
1990
期刊：
影响因子：
3.7
通讯作者：
Poulin,L
中科院分区：
文献类型：
--
作者：
Levy,JA;Ferro,F;Lennette,ET;Oshiro,L;Poulin,L
从HIV感染者唾液中分离的人疱疹病毒-6（HHV-6SF）在细胞宿主范围和某些基因组特性方面与所描述的其他HHV-6毒株不同。HHV-6SF在成人外周血单个核细胞（PMC）中的复制明显优于在胎儿脐带血PMC中的复制，并且只能在MT-4建立的T细胞系中生长。它优先感染CD 4+淋巴细胞，但可以在CD 8+细胞和外周血巨噬细胞中复制。它还感染神经母细胞瘤细胞和胃肠道来源的细胞系。后者的结果表明，这种疱疹病毒可能在影响这些组织的疾病中发挥作用。最后，HHV-6SF的限制性内切酶图谱不同于其他HHV-6毒株。这种独特的HHV-6毒株的鉴定可能表明，迄今为止在其他疱疹病毒中未观察到的病毒分离株之间的不寻常的生物学变异。
An isolate of the human herpesvirus-6 (HHV-6SF) recovered from the saliva of an HIV-infected individual differs in its cellular host range and certain genomic properties from other HHV-6 strains described. HHV-6SF replicates in adult peripheral blood mononuclear cells (PMC) substantially better than in fetal cord blood PMC and can be grown only in the MT-4 established T cell line. It preferentially infects CD4+ lymphocytes but can replicate in CD8+ cells and peripheral blood macrophages. It also infects neuroblastoma cells and cell lines derived from the gastrointestinal tract. These latter results suggest that this herpesvirus could play a role in disorders affecting these tissues. Finally, the restriction enzyme pattern of HHV-6SF differs from that of other HHV-6 strains. The identification of this distinct HHV-6 strain could indicate an unusual biologic variation among viral isolates thus far not observed with other herpesviruses.