Can oral cholera vaccination play a role in controlling a cholera outbreak?
Can oral cholera vaccination play a role in controlling a cholera outbreak?
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DOI：
10.1016/j.vaccine.2003.11.070
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发表时间：
2004-06-23
期刊：
影响因子：
5.5
通讯作者：
Chaignat, CL
中科院分区：
文献类型：
--
作者：
Calain, P;Chaine, JP;Chaignat, CL
限制波恩佩岛（密克罗尼西亚）霍乱疫情蔓延的控制措施包括大规模接种单剂口服霍乱减毒活疫苗CVD 103-HgR，作为一项潜在的辅助措施。这次爆发为评估这种疫苗的实用性和有效性提供了一个独特的机会。在波恩佩的田间条件下，目标人群中的粗疫苗有效性估计为79.2%（95% CI：71.9-84.6%）。回顾性分析表明，口服霍乱疫苗的大规模接种可以成为控制疫情的一个有用的辅助工具，特别是如果与其他标准控制措施一起及早实施。(C)2004年世界卫生组织。由爱思唯尔有限公司出版。保留所有权利。
Control measures to limit the spread of a cholera outbreak in Pohnpei Island (Micronesia), included mass vaccination with the single-dose live-attenuated oral cholera vaccine CVD 103-HgR as a potential adjunct measure. The outbreak provided a unique opportunity to evaluate the practicality of use and effectiveness of this vaccine. Under field conditions encountered in Pohnpei, crude vaccine efficacy was estimated at 79.2% (95% Cl: 71.9-84.6%) in the target population. Retrospective analysis suggests that mass vaccination with oral cholera vaccines can be a useful adjunct tool for controlling outbreaks, particularly if implemented early in association with other standard control measures. (C) 2004 World Health Organization. Published by Elsevier Ltd. All rights reserved.