Development of Amygdala Functional Connectivity During Infancy and Its Relationship With 4-Year Behavioral Outcomes
Development of Amygdala Functional Connectivity During Infancy and Its Relationship With 4-Year Behavioral Outcomes
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DOI：
10.1016/j.bpsc.2018.08.010
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发表时间：
2019-01-01
影响因子：
5.9
通讯作者：
Gao, Wei
中科院分区：
文献类型：
--
作者：
Salzwedel, Andrew P.;Stephens, Rebecca L.;Gao, Wei
背景：杏仁核是人类大脑情绪信号处理回路的核心节点。鉴于其关键作用，杏仁核的典型和非典型功能连接模式已在成人中得到广泛研究。然而，杏仁核功能连接在婴儿期的发展研究较少;因此，我们对关键时期关键情绪相关脑回路的正常生长轨迹的理解是有限的。方法：在本研究中，我们使用静息态功能磁共振成像（N = 233名受试者，334个数据集），以描绘在生命的前2年杏仁核功能连接发展的时空动态。他们与四年情感的关系（即，焦虑和抑制性自我控制父母报告测量）和认知（即，IQ）行为的结果也进行了评估，使用multivariate modeling.RESULTS：我们的研究结果显示，杏仁核功能连接的非线性增长，在生命的头2年，具有戏剧性的同步在第一年，其次是适度增长或微调在第二年。重要的是，在第二年的功能连接的增长有显着的行为影响，例证了4年的情感和认知发展结果的多个显着预测。描述婴儿期杏仁核功能连接发展的时空动态及其与4-年的行为结果可能为典型和非典型情绪加工能力的早期出现提供新的参考。
BACKGROUND: The amygdala represents a core node in the human brain's emotional signal processing circuitry. Given its critical role, both the typical and atypical functional connectivity patterns of the amygdala have been extensively studied in adults. However, the development of amygdala functional connectivity during infancy is less well studied; thus, our understanding of the normal growth trajectory of key emotion-related brain circuits during a critical period is limited.METHODS: In this study, we used resting-state functional magnetic resonance imaging (N = 233 subjects with 334 datasets) to delineate the spatiotemporal dynamics of amygdala functional connectivity development during the first 2 years of life. Their relationships with 4-year emotional (i.e., anxiety and inhibitory self-control parent report measures) and cognitive (i.e., IQ) behavioral outcomes were also assessed using multivariate modeling.RESULTS: Our results revealed nonlinear growth of amygdala functional connectivity during the first 2 years of life, featuring dramatic synchronization during the first year followed by moderate growth or fine tuning during the second year. Importantly, functional connectivity growth during the second year had significant behavioral implications exemplified by multiple significant predictions of 4-year emotional and cognitive developmental outcomes.CONCLUSIONS: The delineation of the spatiotemporal dynamics of amygdala functional connectivity development during infancy and their associations with 4-year behavioral outcomes may provide new references on the early emergence of both typical and atypical emotion processing capabilities.