Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk.
Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk.
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DOI：
10.1017/jns.2021.73
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发表时间：
2021
影响因子：
2.5
通讯作者：
Emerson SR
中科院分区：
文献类型：
--
作者：
Keirns BH;Sciarrillo CM;Koemel NA;Emerson SR
长期以来，空腹三酰甘油与心血管疾病（CVD）和其他心脏代谢疾病有关。有证据表明，非空腹甘油三酯（即在进食后8小时内测量）比空腹甘油三酯更好地预测CVD，这使得一些组织推荐非空腹血脂面板作为新的临床标准。然而，与非空腹甘油三酯测量相关的非标准化评估方案可能会导致错误分类，从而忽略了风险个体。第三种类型的甘油三酯的评估，餐后测试，是更多的控制，但历史上一直难以实施，由于所需的时间和精力来执行it.Here，我们审查的差异评估，基础生理和病理生理相关性升高空腹，非空腹和餐后甘油三酯。我们还提供的数据表明，餐后甘油三酯可能有一个明显的优势，甚至超过非空腹甘油三酯，为早期检测心血管疾病的风险，并提供建议，使餐后方案更具临床可行性。
Fasting triacylglycerols have long been associated with cardiovascular disease (CVD) and other cardiometabolic conditions. Evidence suggests that non-fasting triglycerides (i.e. measured within 8 h of eating) better predict CVD than fasting triglycerides, which has led several organisations to recommend non-fasting lipid panels as the new clinical standard. However, unstandardised assessment protocols associated with non-fasting triglyceride measurement may lead to misclassification, with at-risk individuals being overlooked. A third type of triglyceride assessment, postprandial testing, is more controlled, yet historically has been difficult to implement due to the time and effort required to execute it. Here, we review differences in assessment, the underlying physiology and the pathophysiological relevance of elevated fasting, non-fasting and postprandial triglycerides. We also present data suggesting that there may be a distinct advantage of postprandial triglycerides, even over non-fasting triglycerides, for early detection of CVD risk and offer suggestions to make postprandial protocols more clinically feasible.