Kinetic and theoretical studies of novel biodegradable thermo-sensitive xerogels based on PEG/PVP/silica for sustained release of enrofloxacin
Kinetic and theoretical studies of novel biodegradable thermo-sensitive xerogels based on PEG/PVP/silica for sustained release of enrofloxacin
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DOI：
10.1016/j.apsusc.2017.07.046
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发表时间：
2017-12-15
影响因子：
6.7
通讯作者：
Mohammadi, Masoumah
中科院分区：
文献类型：
--
作者：
Ebadi, Azra;Rafati, Amir Abbas;Mohammadi, Masoumah
本研究涉及一种新的硅基胶体杂化体系的合成。在这个新的杂化体系中，聚乙二醇(PEG)和热敏性两亲性生物相容聚乙烯吡咯烷酮(PVP)被用来创建适合于疏水药物的存储。利用不同的PVP/PEG摩尔比来调节二氧化硅纳米颗粒的药物释放速率是目前研究的主要目标。此外，还对药物释放动力学进行了考察。为了实现这一目标，采用了一种简单的杂化材料合成策略，避免了浪费和多步过程，在聚乙二醇(PEG)和聚乙烯吡咯烷酮(PVP)溶液中加入恩诺沙星(EFX)(作为模型疏水药物)合成了二氧化硅纳米颗粒。考察了PVP/PEG摩尔比、释放介质温度和pH对释放动力学的影响。用傅立叶变换红外光谱(FT-IR)、扫描电子显微镜(SEM)和热重分析(TGA)研究了载药复合材料的物理化学性质。体外释药研究表明，药物释放速率符合Ritger-Peppas方程和Sahlin-Peppas方程。通过对实验数据的分析，在非Fickian扩散控制过程中，药物释放速率符合Ritger-Peppas和Sahlin-Peppas方程。(C)2017爱思唯尔B.V.保留所有权利。
This study involves the synthesis of a new silica-based colloidal hybrid system. In this new hybrid system, poly (ethylene glycol) (PEG) and thermo-sensitive amphiphilic biocompatible poly (vinyl pyrrolidone) (PVP) were used to create suitable storage for hydrophobic drugs. The possibility of using variable PVP/PEG molar ratios to modulate drug release rate from silica nanoparticles was a primary goal of the current research. In addition, an investigation of the drug release kinetic was conducted. To achieve this, silica nanoparticles were synthesized in poly (ethylene glycol) (PEG) and poly (vinyl pyrrolidone) (PVP) solution incorporated with enrofloxacin (EFX) (as a model hydrophobic drug), using a simple synthetic strategy of hybrid materials which avoided waste and multi-step processes. The impacts of PVP/PEG molar ratios, temperature, and pH of the release medium on release kinetic were investigated. The physicochemical properties of the drug-loaded composites were studied by Fourier transform infrared (FT-IR) spectra, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). In vitro drug release studies demonstrated that the drug release rate, which was evaluated by analyzing the experimental data with seven kinetic models in a primarily non-Fickian diffusion-controlled process, aligned well with both Ritger-Peppas and Sahlin-Peppas equations. (C) 2017 Elsevier B.V. All rights reserved.