Fabrication and characterization of quartz nanopillars for DNA separation by size
Fabrication and characterization of quartz nanopillars for DNA separation by size
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DOI：
10.1143/jjap.46.2771
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发表时间：
2007-04-01
期刊：
影响因子：
--
通讯作者：
Horiike, Yasuhiro
中科院分区：
文献类型：
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作者：
Ogawa, Ryo;Kaji, Noritada;Horiike, Yasuhiro
我们制作了两种不同分布的纳米柱-倾斜和正方形分布。在制造包含这些纳米柱的芯片时存在困难，特别是在Ni电镀和石英键合中。我们通过施加稳定的电流和石英键合的可靠性来改进Ni电镀。在具有正方形分布的纳米柱中，DNA显示出构象变化，并且没有显示出任何爬行运动，而是以直线移动，与其在具有倾斜分布的纳米柱中的行为形成对比。具有倾斜分布的纳米柱有效地充当了用于按尺寸分离DNA的筛子。
We fabricated two different distributions of nanopillars-tilted and square distributions. There are difficulties in fabricating a chip containing these nanopillars, particularly in Ni plating, and quartz bonding. We improved the Ni plating by applying stable electric current and the reliability of the quartz bonding. In nanopillars with a square distribution, DNA showed conformational changes, and did not show any reptile motion, but moved in a straight line in contrast with its behavior in nanopillars with a tilted distribution. Nanopillars with a tilted distribution acted effectively as sieves for DNA separation by size.