Distraction modulates anterior cingulate gyrus activations during the cold pressor test
Distraction modulates anterior cingulate gyrus activations during the cold pressor test
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DOI：
10.1006/nimg.2001.0883
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发表时间：
2001-10-01
期刊：
影响因子：
5.7
通讯作者：
Rémy, F
中科院分区：
文献类型：
--
作者：
Frankenstein, UN;Richter, W;Rémy, F
前扣带回(ACG)是神经网络的一部分，与诸如疼痛体验等需要注意的任务有关。然而，ACG内对认知需求和痛苦刺激做出反应的区域并不相同。由于将注意力从痛苦的刺激上转移出来会降低感知到的疼痛强度，我们假设，从疼痛中分心会导致ACG亚区对痛苦刺激的反应减少，而对分心任务的激活亚区的反应增加。BOLD功能磁共振成像具有相对较高的空间分辨率，与其他神经成像技术相比，可以更好地识别ACG次区域反应。12名受试者接受了冷加压测试(CPT)、言语注意任务(VAT)和分心任务(DT)(CPT和VAT的组合)的测试。使用如在SPM99中实现的一般线性模型在逐个体素的基础上执行分析。除了CPT和VAT共同的ACG激活外，我们在与BA24‘相对应的区域中发现了一个CPT特异性簇。通过对比(CPT-DT)和(DT-CPT)评价分心对疼痛的调制作用。为了支持我们的假设，对比(CPT-DT)显示在DT期间BA24‘降低，而对比(DT-CPT)显示BA32/32’的激活增加。这些数据表明，对疼痛的分心和随之而来的低疼痛评级反映在不同的ACG次区域反应中。(C)2001年学术出版社。
The anterior cingulate gyrus (ACG) is part of a neural network implicated in attention-demanding tasks, such as the experience of pain. However, the regions within the ACG responding to cognitive demands and to painful stimulation are not identical. Since directing attention away from a painful stimulus is known to reduce the perceived pain intensity, we hypothesized that distraction from pain would result both in decreased activation of ACG subregions responsive to painful stimulation and increased activation subregions responsive to the distraction task. BOLD fMRI has comparatively high spatial resolution and allows for better identification of ACG subregional responses than other neuroimaging techniques. Twelve subjects were tested using the cold pressor test (CPT), a verbal attention task (VAT), and a distraction task (DT) (a combination of the CPT and VAT). Analysis was performed on a voxel-by-voxel basis using a general linear model as implemented in SPM99. In addition to ACG activations common to both the CPT and VAT, we identified one CPT-specific cluster in an area corresponding to BA24'. The modulation effect of distraction on pain was assessed by contrasting (CPT-DT) and (DT-CPT). In support of our hypothesis, contrast (CPT-DT) revealed a decrease in BA24' during the DT and contrast (DT-CPT) showed increased activation in BA32/32'. These data suggest that distraction from pain and concomitant low pain ratings are reflected in distinct ACG subregional responses. (C) 2001 Academic Press.