Regulatory T cells and transcription factors: gatekeepers in allergic inflammation.
Regulatory T cells and transcription factors: gatekeepers in allergic inflammation.
复制标题
调节性 T 细胞和转录因子：过敏性炎症的看门人。
DOI：
10.1016/j.coi.2004.09.006
复制
发表时间：
2004
影响因子：
7
通讯作者：
Chen,Wanjun
中科院分区：
文献类型：
--
作者：
Wahl,SharonM;Vazquez,Nancy;Chen,Wanjun
抗原引起的CD4+T细胞沿着Th1途径极化通常与自身免疫性和慢性炎症性疾病相关，而对Th2表型的反应的极端偏斜与特应性和过敏性疾病有关。对控制极化的潜在分子机制的浓厚兴趣揭示了一种调节转录因子，这不仅有助于定义这些途径，而且还表明了干预策略的潜在位点。此外，最近鉴定的转录因子与CD4+CD25+调节性T细胞特异性相关，提供了新的线索，在追求定向免疫调节操纵这个群体。继续解开有害免疫反应的发展及其控制的潜在途径将指导新的调查和干预途径。
Antigen-provoked polarization of CD4+T cells along the Th1 pathway is often associated with autoimmune and chronic inflammatory diseases, whereas extreme skewing of the response toward a Th2 phenotype has been linked to atopy and allergic diseases. Intense interest in the underlying molecular mechanisms that control polarization has revealed a contingent of regulatory transcription factors, which not only help to define these pathways but also suggest potential sites for interventional tactics. Moreover, the recent identification of transcription factors specifically associated with CD4+CD25+regulatory T-cells provides new clues regarding manipulation of this population in pursuit of directed immune regulation. Continued unraveling of the pathways underlying the development of deleterious immune responses and their control will guide new avenues of investigation and intervention.