Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
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DOI：
10.1126/science.275.5303.1122
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发表时间：
1997-02-21
期刊：
影响因子：
56.9
通讯作者：
Dixit, VM
中科院分区：
文献类型：
--
作者：
Chinnaiyan, AM;ORourke, K;Dixit, VM
Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-x(L) (a member of the Bcl-2 family of cell death regulators) were both found to interact with and inhibit the function of CED-4. In addition, analysis revealed that CED-4 can simultaneously interact with CED-3 and its mammalian counterparts interleukin-1 beta-converting enzyme (ICE) and FLICE. Thus, CED-4 plays a central role in the cell death pathway, biochemically linking CED-9 and the Bcl-2 family to CED3 and the ICE family of pro-apoptotic cysteine proteases.
