Gonadotrophins: The future.
Gonadotrophins: The future.
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DOI：
10.4103/0974-1208.147490
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发表时间：
2014-10
影响因子：
--
通讯作者：
Patil M
中科院分区：
文献类型：
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作者：
Patil M
IVF临床医生的作用是使ART治疗安全、对患者友好、经济有效，同时提供良好和高质量的治疗。体外受精方案对女性来说是一种负担，也是女性在随后的周期中不回来的潜在原因之一。频繁注射可能会增加压力，也会导致高错误率。简单、短的治疗方案和最佳的高质量卵母细胞恢复可使高质量胚胎发育，随后进行SET治疗，冷冻保存周期负担更小，停药、副作用更小，治疗周期更及时，更具成本效益。开发更长的t1/2末端和更慢的吸收至血清峰值水平的FSH类似物将提高效率，减少副作用，并且易于给药。这便于患者提高依从性。一定的最低LH浓度是足够的鞘细胞功能和随后的颗粒细胞中雌二醇合成所必需的。辅助r-HLH使临床医生能够精确控制LH生物活性的剂量，以靶向治疗窗口。目前正在研究和开发新的肠外、透皮、吸入和口服生育药物和方案，目的是进一步简化抗逆转录病毒治疗。
The role of the IVF clinician is to make the ART treatment safe, patient-friendly, cost effective and at the same time offer good and high quality treatment. IVF protocols are a burden for women and are one of the potential reasons why women don’t return for subsequent cycles. Frequent injections may increase stress and also result in high error rates. Simple short treatment regimen with optimal recovery of good quality oocytes results in development of good quality embryos followed by SET in treatment and cryopreservation cycles are a less burden and result in related lesser discontinuation, side effects, treatment cycles in time and are more cost-effective. Development of FSH analogues with longer terminal t1/2 and slower absorption to peak serum levels will increase the efficiency, decrease the side effects and also is easy to administer. This makes it convenient for the patients increasing the compliance. A certain minimum LH concentration is necessary for adequate thecal cell function and subsequent oestradiol synthesis in the granulosa cells. Adjuvant r-HLH gives clinician's precise control over the dose of LH bioactivity administered to target the therapeutic window. New parenteral, transdermal, inhaled and oral fertility drugs and regimens are currently under research and development with the objective to further simplify treatment for ART.