Three New 18-Oxygenated ent-Kaurane Diterpenoids from Isodon leucophyllus
Three New 18-Oxygenated ent-Kaurane Diterpenoids from Isodon leucophyllus
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DOI：
10.1177/1934578x1000501206
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发表时间：
2010-12
影响因子：
1.8
通讯作者：
Hai Bo Zhang;J. Pu;Yong Zhao;F. He;Wei Zhao;L. Lou;Wei‐Lie Xiao;Han-Dong Sun
中科院分区：
文献类型：
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作者：
Hai Bo Zhang;J. Pu;Yong Zhao;F. He;Wei Zhao;L. Lou;Wei‐Lie Xiao;Han-Dong Sun
从白叶香茶菜（Isodonleucophyllus）地上部分分得3个新的18位含氧对映贝壳杉烷型二萜化合物，即异丁香素A-C（1-3）和10个已知二萜化合物。通过1D和2D NMR光谱分析鉴定了结构。评价了所有化合物的细胞毒性。Rabdokunmin A（13）对HT-29细胞显示出显著的细胞毒性，IC 50值为6.2 μM。
Three new 18-oxygenated ent-kaurane diterpenoids, isoleuconins A-C (1–3) and ten known diterpenoids were isolated from the aerial parts of Isodon leucophyllus. The structures were elucidated by 1D and 2D NMR spectroscopic analysis. All of the compounds were evaluated for their cytotoxicity. Rabdokunmin A (13) showed significant cytotoxicity against HT-29 cells, with an IC50 value of 6.2 μM.