Weight changes and the risk of knee osteoarthritis requiring arthroplasty
Weight changes and the risk of knee osteoarthritis requiring arthroplasty
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DOI：
10.1136/ard.2003.011833
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发表时间：
2004-11-01
影响因子：
27.4
通讯作者：
Suomalainen, O
中科院分区：
文献类型：
--
作者：
Manninen, P;Riihimaki, H;Suomalainen, O
目的：为了研究20和50岁之间的体重变化的影响，对严重的膝关节骨关节炎（OA）的风险，需要arthroplasty.Subjects和方法：病例是55 - 75岁的男性和女性（n = 220）有膝关节置换术原发性骨关节炎在库奥皮奥大学医院在1992 - 93年。对照组（n = 415）从库奥皮奥省的人口中随机选择。通过邮寄问卷回顾性收集了20、30、40和50岁时的体重。结果：在对年龄、性别、体力劳动史、娱乐性体力活动和既往膝关节损伤进行调整后，体重增加导致体重指数偏离正常（BMI小于或等于25 kg/m（2））至超重（BMI> 25 kg/m2）与20 - 50岁持续超重相比，与相应年龄段相对体重正常者比较。OR值为3.07（95%置信区间1.87至5.05）对于20岁时体重正常，30岁、40岁或50岁中有两三岁超重的人，（1.85~5.36），30岁以上超重者，（1.21~4.62）。结论：在成年人中，从正常到超重的转变可能比持续超重带来更高的需要关节成形术的膝关节OA风险。
Objective: To examine the effect of weight changes between 20 and 50 years of age on the risk of severe knee osteoarthritis (OA) requiring arthroplasty.Subjects and methods: Cases were 55-75 year old men and women (n = 220) having had knee arthroplasty for primary osteoarthritis at the Kuopio University Hospital in 1992-93. Controls (n = 415) were randomly selected from the population of Kuopio Province. Weight at the age of 20, 30, 40, and 50 years was collected retrospectively with a postal questionnaire.Results: After adjustment for age, sex, history of physical workload, recreational physical activity, and previous knee injury, weight gain resulting to a shift from normal body mass index (BMI less than or equal to25 kg/m(2)) to overweight (BMI >25 kg/m(2)) was associated with a higher relative risk of knee OA requiring arthroplasty than persistent overweight from 20-50 years of age, compared with those with normal relative weight during the corresponding age period. The odds ratios (OR) were 3.07 (95% confidence interval 1.87 to 5.05) for those with normal weight at the age of 20 years and overweight at two or three of the ages 30, 40 or 50 years, 3.15 (1.85 to 5.36) for those with overweight from the age of 30 years, and 2.37 (1.21 to 4.62) for those with overweight from the age of 20 years, respectively.Conclusion: In adult life, a shift from normal to overweight may carry a higher risk for knee OA requiring arthroplasty than does constant overweight.