Apoptosis and the airway epithelium.
Apoptosis and the airway epithelium.
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DOI：
10.1155/2011/948406
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
White SR
中科院分区：
文献类型：
--
作者：
White SR
气道上皮细胞在肺中起屏障和宿主防御的前线作用。细胞凋亡或程序性细胞死亡可以在上皮中作为对病毒感染、暴露于过敏原或环境毒素或药物的应答而引起。虽然细胞凋亡可以通过激活细胞表面上的死亡受体或通过破坏线粒体极性来诱导，但与炎性细胞相比，上皮细胞对细胞凋亡刺激更具抗性。本文着重介绍了正常状态下气道上皮细胞对凋亡的反应，凋亡作为气道上皮细胞数量和类型的潜在调节因子，以及上皮细胞凋亡在重要气道疾病中的作用。
The airway epithelium functions as a barrier and front line of host defense in the lung. Apoptosis or programmed cell death can be elicited in the epithelium as a response to viral infection, exposure to allergen or to environmental toxins, or to drugs. While apoptosis can be induced via activation of death receptors on the cell surface or by disruption of mitochondrial polarity, epithelial cells compared to inflammatory cells are more resistant to apoptotic stimuli. This paper focuses on the response of airway epithelium to apoptosis in the normal state, apoptosis as a potential regulator of the number and types of epithelial cells in the airway, and the contribution of epithelial cell apoptosis in important airways diseases.