Pyloric stenosis in the Oxford Record Linkage Study area.
Pyloric stenosis in the Oxford Record Linkage Study area.
复制标题
牛津记录关联研究领域的幽门狭窄。
DOI：
10.1136/jmg.13.6.439
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发表时间：
1976
影响因子：
4
通讯作者：
J. Fedrick
中科院分区：
文献类型：
--
作者：
P. Adelstein;J. Fedrick
本研究采用牛津记录关联研究的资料，对1966年至1971年6年间出现婴儿肥厚性幽门狭窄（IHPS）的220例婴儿进行鉴定。这些婴儿的资料是从出生证明和产妇记录中获得的。总发病率为每1000例活产2.5例。存在明显的季节变化，第三季度出生的婴儿发病率最高，不同地区的发病率也不同：城市的IHPS发病率远低于邻近的农村或小城市地区。研究表明，该地区南部和东部的发病率远远高于北部和西部。本组未见超产现象，产妇高峰年龄为20 ~ 24岁；社会第1和第2阶层的父母略多；并且与恒河猴阴性的母亲有显著的联系。兄弟姐妹中患IHPS的比率为85 / 1000。虽然通常与男性性别相关（M:F比= 5.5:1），但与出生体重没有变化，只有在女性中发现与妊娠期延长有关。妊娠期与入院年龄呈反比关系。
The files of the Oxford Record Linkage Study were employed to identify 220 infants presenting with infantile hypertrophic pyloric stenosis (IHPS) in the 6-year period 1966 to 1971. Information on these infants was obtained from birth certificates and maternity notes. The overall incidence was 2.5 per 1000 livebirths. There was a distinct seasonal variation, with highest incidence to infants born in the third quarter of the year as well as variation in incidence with area: the cities had much lower rates of IHPS than the adjacent rural or small urban areas. It was shown that the rates in the south and east of the area studied were far greater than in the north and west. In the present study there was no excess of primiparae, the peak maternal age group was 20 to 24; there was a slight excess of parents of social classes I and II; and a significant association with mothers who were Rhesus negative. The rate of IHPS among sibs was 85 per 1000. Though there was the usual correlation with the male sex (M:F ratio = 5.5:1), there was no variation with birthweight and only among the females was an association found with prolonged gestation. There appeared to be an inverse relation between gestation and age on admission to hospital.