Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation.
Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation.
复制标题
DOI：
--
复制
发表时间：
1990-04
期刊：
影响因子：
--
通讯作者：
H. Baumann;J. Gauldie
中科院分区：
文献类型：
--
作者：
H. Baumann;J. Gauldie
肝脏对全身性损伤的反应以几种功能必需的血浆蛋白的表达协同增加为特征。已经确定了负责初始肝脏刺激的因素，包括细胞因子IL-1（白细胞介素-1），肿瘤坏死因子α (TNF α), IL-6（白细胞介素-6），肝细胞刺激因子iii （HSF-III）以及皮质类固醇。受调节蛋白的绝对表达水平似乎受到预先存在的肝脏激素环境和急性期反应期间发生的环境变化的调节。糖皮质激素、IL-1和蛋白激酶C的激活的具体作用在本研究中得到了解决。为了预测急性期肝脏反应的表型，必须确定所有炎症细胞因子的肝脏活性。此外，必须认识到，肝脏环境本身可以调节肝脏对这些细胞因子的合成代谢反应。在确定慢性炎症进展过程中所见的变化时，也需要同样的考虑。
The hepatic response to systemic injury is characterized by a co-ordinated increase in the expression of several, functionally essential plasma proteins. The factors responsible for initial hepatic stimulation have been identified and include the cytokines IL-1 (interleukin-1), tumor necrosis factor alpha (TNF alpha), IL-6 (interleukin-6), hepatocyte-stimulating factor-III (HSF-III) as well as corticosteroids. The absolute level of expression of the regulated proteins appears to be modulated by the pre-existing hepatic hormonal environment and changes to that environment that occur during acute phase reactions. The specific effects of glucocorticoids, IL-1 and activation of protein kinase C are addressed in this study. In order to predict the phenotype of liver response in acute phase, the hepatic activities of all inflammatory cytokines present must be established. Moreover, it must be recognized that the hepatic environment itself can modulate the anabolic response of the liver to these cytokines. The same considerations are needed when determining the changes seen during the progression to chronic inflammation.