Signalling pathways and vascular calcification
Signalling pathways and vascular calcification
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DOI：
10.2741/3790
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Shanahan, Catherine M.
中科院分区：
文献类型：
--
作者：
Liu, Yiwen;Shanahan, Catherine M.
血管钙化是心血管疾病发病率和死亡率的主要危险因素。全面了解介导血管钙化的信号通路至关重要，不仅因为这种病理学在疾病中的重要性，而且对于探索潜在的治疗靶点也至关重要。临床上，需要开发治疗方法来预防或甚至逆转动脉粥样硬化、慢性肾病、糖尿病和衰老情况下的钙化。在这篇简短的综述中，我们打算探讨最初的触发因素，这些触发因素通常与不同疾病情况下的钙化有关，并研究引发血管钙化过程的下游信号通路。特别是，我们试图解剖这些途径，并检查不同的信号通路之间的串扰。我们的重点是血管平滑肌细胞（VSMC），因为它最终是这些细胞的表型调节，可能会驱动钙化过程。
Vascular calcification is a major risk factor for cardiovascular morbidity and mortality. A full understanding of the signalling pathways mediating vascular calcification is crucial not just because of the importance of this pathology in disease, but also for exploring potential therapeutic targets. Clinically there is a need to develop therapies to prevent or even reverse calcification in situations of atherosclerosis, chronic kidney disease, diabetes, and aging. In this brief review, we intend to explore the initial triggers, which are commonly related to calcification in different disease scenarios and examine the downstream signalling pathways that instigate the process of vascular calcification. In particular, we try to dissect these pathways and also examine cross-talk between different signalling pathways. Our focus is the vascular smooth muscle cell (VSMC) as it is ultimately the phenotypic modulation of these cells that may drive the calcification process.