Recurrent headache and MRI findings in systemic lupus erythematosus
Recurrent headache and MRI findings in systemic lupus erythematosus
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DOI：
10.1016/s0027-9684(15)31245-1
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发表时间：
2008-03-01
影响因子：
3.3
通讯作者：
Sarica, Yakup
中科院分区：
文献类型：
--
作者：
Bicakci, Sebnem;Ozbek, Suleyman;Sarica, Yakup
背景：系统性红斑狼疮 (SLE) 患者的头痛被认为是一种常见的神经系统表现，尽管其关系尚不清楚。另一个模糊点是这些患者的头痛与神经放射学结果之间的关系。目的：在本研究中，我们旨在评估 SLE 患者的头痛特征与颅内病变之间的相关性。方法和结果：根据美国风湿病学会（ACR）诊断 SLE 时或诊断后的标准，从转诊至我们诊所的 48 例 SLE 患者中选择。根据 ICD-II 标准对患者进行头痛分类。通过视觉模拟量表（VAS）评估头痛严重程度，VAS A受试者被纳入研究。根据磁共振成像（MRI）结果将患者分为两组：MRI异常（病变阳性）和MRI正常（病变阴性）。 MRI显示，37.5%（n=18）的患者发现颅内病变，62.5%（n=30）的患者未发现颅内病变。所有患者中，54.1%（n=26）的头痛特征为紧张型，39.6%（n=19）为偏头痛。影像学表现大多为脑室周围和皮质下局灶性病变，直径范围为3-22毫米。 MRI 异常结果与高龄和病程延长之间存在显着相关性（p=0.018，p=0.016）。 结论：作为结论，无论头痛特征如何，对于病程长、病程长的 SLE 患者，如有必要，应进行详细的神经学评估和放射学检查（如有必要）。
Background: Headache in patients with systemic lupus eryhtemotosus (SLE) is considered a common neurological finding, although the relationship is unclear. Another obscure point is the relationship between headache and neuroradiologic findings in these patients.Aim: In this study, we aimed to evaluate the correlation between headache characteristics and intracranial lesions in SLE patients.Methods and Results: Forty-eight SLE patients were chosen from those referred to our clinic depending on the American Collage of Rheumatology (ACR) criteria at the some time or after the diagnosis of SLE. Headache classification was done regarding the ICD-II criteria in the patients. Headache severity was assessed by visual analog scale (VAS), and subjects with VAS A were included in the study.Patients were divided into two groups according to magnetic resonance imaging (MRI) findings: abnormal MRI (lesion positive) and normal MRI (lesion negative). On MRI, intracranial lesions were detected in 37.5 % (n= 18) of the patients, and no lesion was found in 62.5% (n=30). Headache characteristics were as tension type in 54.1 % (n=26) and migraine like in 39.6% (n=19) of all patients. Imaging findings were mostly as periventricular and subcortical focal lesions, ranging from 3-22 mm in diameter. A significant correlation was found between abnormal MRI findings with advanced age and prolonged disease duration (p=0.018, p=0.016).Conclusions: As a conclusion, a detailed neurologic evaluation and radiologic investigation, if necessary, should be performed in SLE patients with prolonged disease and advanced age, regardless of headache characteristics.