Correlation of Fc-γ RIIA polymorphisms with latent Epstein-Barr virus infection and latent membrane protein 1 expression in patients with low grade B-cell lymphomas
Correlation of Fc-γ RIIA polymorphisms with latent Epstein-Barr virus infection and latent membrane protein 1 expression in patients with low grade B-cell lymphomas
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DOI：
10.3109/10428194.2012.762512
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发表时间：
2013-09-01
影响因子：
2.6
通讯作者：
Viniou, Nora-Athina
中科院分区：
文献类型：
--
作者：
Diamantopoulos, Panagiotis T.;Kalotychou, Vassiliki;Viniou, Nora-Athina
Fc-gamma RIIA (CD32) 是 Fc-g 受体家族的成员，参与与抗体抗原结合的吞噬作用。根据最近的研究，该功能的有效性因其几种单倍型而异，并且它参与病毒感染的发病机制。 Fc-gamma RIIA 的遗传位点由两个等位基因组成：131-Arg (R131) 和 131-His (H131)。我们的目的是通过使用 PCR-RFLP（聚合酶链反应限制性片段长度多态性）研究每个等位基因的患病率，将 Fc-gamma RIIA 多态性与 40 名白血病低度 B 细胞淋巴瘤患者的潜伏 Epstein-Barr 病毒 (EBV) 感染和潜伏膜蛋白 1 (LMP1) 的表达相关联。 R131 存在于 84.2% 的 EBV 阳性患者中，但仅存在于 28.5% 的 EBV 阴性患者中 (p = 0.001)。 R131 和 LMP1 表达也存在类似的相关性（84.6% vs. 28.5%）（p = 0.002）。我们的结果支持这样的假设：Fc-gamma RIIA 多态性是潜在 EBV 感染及其致癌潜伏蛋白表达的遗传危险因素。
Fc-gamma RIIA (CD32), a member of the family of Fc-g receptors, participates in the phagocytosis of bound to antibody antigens. The effectiveness of this function varies for its several haplotypes, and it participates in the pathogenesis of viral infections, according to recent studies. The genetic locus of Fc-gamma RIIA consists of two allelic genes: 131-Arg (R131) and 131-His (H131). Our aim was to correlate Fc-gamma RIIA polymorphisms, by studying the prevalence of each allele using PCR-RFLPs (polymerase chain reaction-restriction fragment length polymorphisms), with latent Epstein-Barr virus (EBV) infection and the expression of latent membrane protein 1 (LMP1) in 40 patients with leukemic low grade B-cell lymphomas. R131 was found in 84.2% of EBV-positive patients, but only in 28.5% of EBV-negative patients (p = 0.001). A similar correlation was found for R131 and LMP1 expression (84.6% vs. 28.5%) (p = 0.002). Our results support the hypothesis that Fc-gamma RIIA polymorphisms are a genetic risk factor for latent EBV infection and the expression of its oncogenic latency proteins.