Childhood Trauma and Functional Connectivity between Amygdala and Medial Prefrontal Cortex: A Dynamic Functional Connectivity and Large-Scale Network Perspective.
Childhood Trauma and Functional Connectivity between Amygdala and Medial Prefrontal Cortex: A Dynamic Functional Connectivity and Large-Scale Network Perspective.
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DOI：
10.3389/fnsys.2017.00029
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发表时间：
2017
影响因子：
3
通讯作者：
Cisler JM
中科院分区：
文献类型：
--
作者：
Cisler JM
内侧前额叶皮层（mPFC）和杏仁核之间的功能连接（FC）改变被广泛认为是解释早期生活创伤患者精神病理学风险的神经机制。尽管如此，当代神经影像学研究已经转向大脑功能的大规模网络模型，目前尚不清楚这种常见的双节点发现如何适应更大规模的网络模型。在这里，使用动态功能连接（DFC）的方法结合大规模的网络分析，mPFC和杏仁核之间的样本的青春期女孩的双节点FC的更大的作用进行了调查。样本由30名健康对照女孩和26名暴露于身体或性侵犯的女孩组成，这些女孩在3 T MRI期间接受了静息状态扫描。使用滑动窗口方法的DFC被用来创建加权的，无向的，从静止状态数据后，与215个感兴趣的区域（ROI）的地图集分割的图形。使用先验ROI，预测发现出租人FC之间的mPFC和杏仁核作为早期生活创伤的功能在这个样本中复制。相比之下，早期生活创伤与更大规模的网络模块化有关。使用动态FC的方法，它也表明，在这个双节点FC的受试者内的变化密切跟踪受试者内的波动，在大规模的网络模式，包括边缘系统和默认模式网络（其中杏仁核和mPFC节点属于，分别）之间的连接，以及整体模块化组织。这些结果表明，双节点FC，如杏仁核-mPFC FC，通常可以反映更大规模的网络模式。未来的研究是必要的，以了解节点FC和大规模网络组织之间的这些关联是否更好地反映自上而下的过程（大规模网络组织驱动双节点FC）或自下而上的过程（双节点FC驱动大规模网络组织）和早期生活创伤的相关影响。
Altered functional connectivity (FC) between the medial prefrontal cortex (mPFC) and amygdala is widely implicated as a neural mechanism explaining risk for psychopathology among those exposed to early life trauma. Nonetheless, contemporary neuroimaging research has shifted toward large-scale network models of brain function, and it is not clear how this common bi-nodal finding fits into larger-scale network models. Here, using dynamic functional connectivity (DFC) approaches combined with large-scale network analyses, the larger role of bi-nodal FC between mPFC and amygdala among a sample of adolescent girls is investigated. The sample was comprised of 30 healthy control girls and 26 girls exposed to either physical or sexual assault who underwent a resting-state scan during 3T MRI. DFC using a sliding window approach was used to create weighted, undirected, graphs from the resting-state data following parcellation with a 215 regions-of-interest (ROI) atlas. Using a priori ROI, the predicted finding of lessor FC between mPFC and amygdala as a function of early life trauma was replicated in this sample. By contrast, early life trauma was associated with greater large-scale network modularity. Using a dynamic FC approach, it is also demonstrated that within-subject variability in this bi-nodal FC closely tracks within-subject fluctuations in large-scale network patterns, including connectivity between a limbic and default mode network (in which the amygdala and mPFC nodes belong, respectively) as well as overall modular organization. These results suggest that bi-nodal FC, such as amygdala-mPFC FC, may generally reflect larger-scale network patterns. Future research is necessary to understand whether these associations between nodal FC and large-scale network organization better reflect top-down processes (larger-scale network organization drives bi-nodal FC) or bottom-up processes (bi-nodal FC drives larger-scale network organization) and the related impact of early life trauma.