Antenatal steroid exposure and pulmonary outcomes in adolescents born with very low birth weight
Antenatal steroid exposure and pulmonary outcomes in adolescents born with very low birth weight
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DOI：
10.1038/jp.2013.69
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发表时间：
2013-10-01
影响因子：
2.9
通讯作者：
O'Shea, T. M.
中科院分区：
文献类型：
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作者：
Nixon, P. A.;Washburn, L. K.;O'Shea, T. M.
目的：比较极低出生体重早产儿在产前激素暴露和不暴露的情况下的哮喘史和肺功能。研究设计：我们研究了188名14岁的青少年(94名暴露，84名男性)。我们使用父母报告来确定哮喘和哮喘相关症状，并使用肺活量测定来评估肺功能。使用Mann-Whitney U检验(连续变量)、w2分析(分类变量)和Logistic回归(多变量分析)对激素暴露组和非激素暴露组进行比较。结果：激素暴露组有更大的呼吸道阻塞发生率(35%比21%)，出生体重1000克的类固醇暴露青少年发生更大呼吸道阻塞的几率是对照组的4.5倍。在过去12个月中，出生体重在1000到1500克之间的暴露于类固醇的青少年中，喘息的发生率是后者的两倍。结论：在表面活性物质治疗的时代，产前暴露于类固醇并不能为早产儿和极低出生体重的青少年的肺部结局提供长期益处。
OBJECTIVE: To compare asthma history and pulmonary function in adolescents born prematurely with very low birth weight with and without antenatal steroid exposure.STUDY DESIGN: We studied 188 fourteen-year olds (94 exposed, 84 male). We used parent report to ascertain asthma and asthma-related symptoms and spirometry to assess pulmonary function. Steroid-exposed and -unexposed groups were compared using Mann-Whitney U-tests (continuous variables), w 2 analysis (categorical variables) and logistic regression (multivariate analyses).RESULT: The steroid-exposed group had greater prevalence of larger airway obstruction (35% vs 21%), and steroid-exposed adolescents with birth weightso1000 g had 4.5-fold higher odds of larger airway obstruction. Wheezing in the past 12 months was two times as prevalent in steroid-exposed adolescents with birth weights between 1000 and 1500 g.CONCLUSION: Antenatal steroid exposure does not provide long-term benefits for pulmonary outcomes in adolescents born prematurely with very low birth weight in the era of surfactant therapy.