FOOD-DEPRIVATION INCREASES ORAL AND INTRAVENOUS DRUG INTAKE IN RATS
FOOD-DEPRIVATION INCREASES ORAL AND INTRAVENOUS DRUG INTAKE IN RATS
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DOI：
10.1126/science.36665
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发表时间：
1979-01-01
期刊：
影响因子：
56.9
通讯作者：
MEISCH, RA
中科院分区：
文献类型：
--
作者：
CARROLL, ME;FRANCE, CP;MEISCH, RA
在饮用水(5微克/毫升)中连续给予依硝氮烯盐酸盐的大鼠，在不进食的情况下，药物摄入量增加了一倍以上。另一组植入颈静脉导管的大鼠，静脉注射乙硝唑(10u.g/kg)。在持续的强化时间表上，在他们被剥夺食物的日子里，输液的次数显著增加。喂养条件可能是药物强化行为的一个强有力的决定因素。[这种食物剥夺效应发生在人类滥用的四大类药物中。]
Rats given continuous access to etonitazene HCL in their drinking water (5 .mu.g/ml) more than doubled their drug intake while deprived of food. Another group of rats with implanted jugular catheters self administered etonitazene (10 .mu.g/kg) i.v. on a continuous reinforcement schedule, and the number of infusions increased significantly on days when they were deprived of food. Feeding condition may be a powerful determinant of drug-reinforced behavior. [This food deprivation effect occurs with drugs from the 4 major classes of drugs abused by humans.].