AGENT OF DISEASE CONTRACTED FROM GREEN MONKEYS
AGENT OF DISEASE CONTRACTED FROM GREEN MONKEYS
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DOI：
10.1126/science.160.3830.888
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发表时间：
1968-01-01
期刊：
影响因子：
56.9
通讯作者：
WHITFIELD, SG
中科院分区：
文献类型：
--
作者：
KISSLING, RE;ROBINSON, RQ;WHITFIELD, SG
从接触非洲绿色猴组织后患病的患者身上获得的传染性病原体具有病毒性质。通过电子显微镜观察，该试剂呈圆柱形，直径为90至100纳米，长度为130至2600纳米。在5纳米的间隔和45纳米的核心直径的交叉条纹进行了观察。该药剂对代谢抑制剂5-溴脱氧尿苷的作用完全耐受，这可能意味着RNA是遗传物质。对乙醚敏感，对热破坏相对敏感。
An infectious agent obtained from patients who became ill after exposure to tissues of African green monkeys is viral in character. By electron microscopy, the agent appeared cylindrical, 90 to 100 nanometers in diameter, and 130 to 2600 nanometers in length. Cross-striations at 5-nanometer intervals and a core diameter of 45 nanometers were observed. The agent was completely resistant to the effects of the metabolic inhibitor 5-bromodeoxyuridine, which may mean that RNA is the genetic material. It was sensitive to ether and relatively sensitive to destruction by heat.