Genetic Characterization of Archived Bunyaviruses and their Potential for Emergence in Australia.
Genetic Characterization of Archived Bunyaviruses and their Potential for Emergence in Australia.
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DOI：
10.3201/eid2205.151566
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发表时间：
2016-05
影响因子：
11.8
通讯作者：
Warrilow D
中科院分区：
文献类型：
--
作者：
Huang B;Firth C;Watterson D;Allcock R;Colmant AM;Hobson-Peters J;Kirkland P;Hewitson G;McMahon J;Hall-Mendelin S;van den Hurk AF;Warrilow D
来自澳大利亚的布尼亚病毒和来自其他地方的致病性布尼亚病毒之间的遗传关系表明了出现的潜力。为了更好地了解布尼亚病毒的多样性及其在澳大利亚的传播，我们对40年前分离并经血清学鉴定为布尼亚病毒科成员的5种病毒（甘甘、特鲁巴纳曼、小万山、亚卡巴和塔格特）进行了测序。甘甘和Trubanaman病毒几乎完全匹配2最近分离的，据称是新的病毒，盐灰和Murrumbidgee病毒，分别。小万山和亚卡巴病毒被鉴定为与包含致病病毒的大型进化枝的成员相关。Taggert病毒被证实是一种内罗病毒;该属的几种病毒对人类具有致病性。小鼠的遗传关系和历史实验感染揭示了这些病毒导致疾病出现的潜力。
Genetic relationships between bunyaviruses from Australia and pathogenic bunyaviruses from elsewhere indicate emergence potential. To better understand the diversity of bunyaviruses and their circulation in Australia, we sequenced 5 viruses (Gan Gan, Trubanaman, Kowanyama, Yacaaba, and Taggert) isolated and serologically identified 4 decades ago as members of the family Bunyaviridae. Gan Gan and Trubanaman viruses almost perfectly matched 2 recently isolated, purportedly novel viruses, Salt Ash and Murrumbidgee viruses, respectively. Kowanyama and Yacaaba viruses were identified as being related to members of a large clade containing pathogenic viruses. Taggert virus was confirmed as being a nairovirus; several viruses of this genus are pathogenic to humans. The genetic relationships and historical experimental infections in mice reveal the potential for these viruses to lead to disease emergence.