High-Transmission-Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally-Invasive Tumor Margin Detection.
High-Transmission-Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally-Invasive Tumor Margin Detection.
复制标题
高传输效率和侧视微型 OIDRS 探头，用于快速、微创肿瘤边缘检测。
DOI：
10.1109/jsen.2010.2076279
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发表时间：
2011
影响因子：
4.3
通讯作者：
Wang,LV
中科院分区：
文献类型：
--
作者：
Garcia-Uribe,A;Chang,C-C;Yapici,MK;Zou,J;Banerjee,B;Kuczynski,J;Ong,E;Marner,ES;Wang,LV
无癌切缘I器官的确定是一个困难和耗时的过程，在手术中快速确定肿瘤切缘的需求尚未得到满足。本文报道了一种具有“侧视”能力的新型小型化光学传感器探头的设计、制作和测试。它史无前例的小巧，独特的侧视能力，以及高的光传输效率，使其即使在人体内狭窄的腔内也能灵活机动和高效地收集数据。传感器探头由四个带有光纤的微机械基板组成，用于斜入射光线并收集接触组织的空间分辨漫反射。利用光学传感探头对人胰腺标本进行了斜入射漫反射光谱(OIDRS)研究。根据测量结果，成功地确定了恶性肿瘤的边缘，与组织学结果吻合较好。
The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with “side-viewing” capability. Its unprecedented small size, unique “side-viewing” capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.