Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning.
Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning.
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DOI：
10.1186/s40942-017-0081-z
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发表时间：
2017
影响因子：
2.3
通讯作者：
Chhablani J
中科院分区：
文献类型：
--
作者：
Alshareef RA;Khuthaila MK;Januwada M;Goud A;Ferrara D;Chhablani J
目的：应用光学相干断层扫描（OCT）分析非病理性近视眼脉络膜的形态学特征。对非病理性近视眼的增强深度SD-OCT图像与年龄匹配的健康对照进行回顾性分析。测量中心凹处的脉络膜厚度（CT）和脉络膜大血管厚度（LCVT），鼻侧距离中心凹750 µm（N750），颞侧距离中心凹750 µm（T750）。通过从CT中减去LCVT来计算中等脉络膜血管厚度（MCVT）。鉴于其厚度减少，脉络膜毛细血管被MCVT所包围。线性回归分析年龄与CT、LCVT、MCVT轴位的关系。研究组包括31名患者的42只眼（平均年龄46.13 ± 15.63; 15名女性）。对照组34例57眼，女性24例，平均年龄42.3 ± 15.29岁。近视眼和对照眼眼的眼轴长度分别为26.57 ± 1.27和23.59 ± 0.99 mm。与对照组相比，近视眼在所有位置均显示MCVT和CT显著变薄（p < 0.0001），与LCVT不同（p > 0.05）。每十年，CT中的变薄量可达37 µm，同时，LCVT（高达22.6 µm）和MCVT（高达25 µm）也会沿着变薄。眼轴长度每增加1 mm，LCVT（<10 µm）脉络膜沿着变薄38.2 µm，而MCVT变薄更明显（>30 µm）。与健康受试者相比，非病理性近视眼的MCVT显著变薄。MCVT与年龄和眼轴长度有较强的相关性。
To analyse morphologic features of the choroid in Non-pathological myopic eyes using spectral-domain (SD) optical coherence tomography (OCT). Retrospective analysis of enhanced depth SD-OCT images of Non-pathological myopic eyes in comparison with age-matched healthy controls was performed. Choroidal thickness (CT) and large choroidal vessel thickness (LCVT) were measured at the fovea, 750 µm nasally from fovea (N750) and 750 µm temporally (T750) from fovea. Medium choroidal vessel thickness (MCVT) was calculated by subtracting LCVT from CT. Choriocapillaris was encompassed by MCVT, given its reduced thickness. Linear regression analysis evaluated the relationship between age and axial with CT, LCVT and MCVT. The study group comprised 42 eyes of 31 patients (mean age 46.13 ± 15.63; 15 females). Control group included 57 eyes of 34 patients (mean age of 42.3 ± 15.29; 24 females). Mean axial length in myopic eyes and control group was 26.57 ± 1.27 and 23.59 ± 0.99 mm respectively. Myopic eyes showed significant thinning of MCVT and CT at all locations (p < 0.0001) compared to controls, unlike LCVT (p > 0.05). With each decade, thinning of up to 37 µm in CT was noted along with thinning of LCVT (up to 22.6 µm) and MCVT (up to 25 µm). Each mm increase in axial length caused 38.2 µm thinning of choroid along with LCVT (<10 µm), however, MCVT showed more notable thinning (>30 µm). Significant thinning of MCVT was noted in non-pathological myopic eyes in comparison to healthy subjects. It appears that MCVT has stronger relationship with age and axial length.