Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats
Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats
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DOI：
10.1101/lm.37601
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发表时间：
2001-05-01
影响因子：
2
通讯作者：
Maren, S
中科院分区：
文献类型：
--
作者：
Goosens, KA;Maren, S
大量的文献表明杏仁核与巴甫洛夫恐惧条件反射有关。在这项研究中，我们研究了单个杏仁核的贡献，大鼠的上下文和听觉恐惧条件反射。在恐惧条件反射之前，大鼠一侧大脑半球的杏仁核受到大的电解质损伤，而对侧大脑半球受到核特异性神经毒性损伤。神经毒性病变针对杏仁核的外侧核（LA）、基底外侧核和基底内侧核（基底核）或中央核（CE）。LA和CE病变减弱了对上下文和听觉条件刺激（CS）的冻结。基底核的病变产生赤字的背景和听觉恐惧条件下，只有当损害扩展到内部部门的基底核：损害局限于后司的基底核没有显着损害条件下，无论是听觉或上下文CS。这些影响通常是不偏侧的，虽然神经毒性病变的后分区的基底核有更大的影响上下文恐惧条件反射时，对侧电解质病变被放置在右半球。这些结果表明，有显着的重叠杏仁核内的神经通路介导的恐惧条件反射的上下文和声学CS，这些形式的学习是不解剖学上的杏仁核的水平分离。
A large body of literature implicates the amygdala in Pavlovian fear conditioning. In this study, we examined the contribution of individual amygdaloid nuclei to contextual and auditory fear conditioning in rats. Prior to fear conditioning, rats received a large electrolytic lesion of the amygdala in one hemisphere, and a nucleus-specific neurotoxic lesion in the contralateral hemisphere. Neurotoxic lesions targeted either the lateral nucleus (LA), basolateral and basomedial nuclei (basal nuclei), or central nucleus (CE) of the amygdala. LA and CE lesions attenuated freezing to both contextual and auditory conditional stimuli (CSs). Lesions of the basal nuclei produced deficits in contextual and auditory fear conditioning only when the damage extended into the Interior divisions of the basal nuclei: damage limited to the posterior divisions of the basal nuclei did not significantly impair conditioning to either auditory or contextual CS. These effects were typically not lateralized, although neurotoxic lesions of the posterior divisions of the basal nuclei had greater effects on contextual fear conditioning when the contralateral electrolytic lesion was placed in the right hemisphere. These results indicate that there is significant overlap within the amygdala in the neural pathways mediating fear conditioning to contextual and acoustic CS, and that these forms of learning are not anatomically dissociable at the level of amygdaloid nuclei.