Highly enantioselective α-chlorination of cyclic β-ketoesters catalyzed by N,N′-Dioxide using NCS as the chlorine source
Highly enantioselective α-chlorination of cyclic β-ketoesters catalyzed by N,N′-Dioxide using NCS as the chlorine source
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DOI：
10.1039/b922769e
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Feng, Xiaoming
中科院分区：
文献类型：
--
作者：
Cai, Yunfei;Wang, Wentao;Feng, Xiaoming
开发了一种简单、高效的N，N‘-二氧化氮有机催化体系，用于环β-酮酯的不对称α-氯化反应。以易得的NCS为氯源，合成了一系列光学活性的α-氯-β-酮酯，产率为90-98%ee。
A simple and highly efficient N,N'-dioxide organocatalyst system was developed for the asymmetric alpha-chlorination of cyclic beta-ketoesters using easily available NCS as the chlorine source to provide a series of optically active alpha-chloro-beta-ketoesters in excellent yields with 90-98% ee.