SPATIAL-LEARNING AND MEMORY, MAZE RUNNING STRATEGIES AND CHOLINERGIC MECHANISMS IN 2 INBRED STRAINS OF MICE
SPATIAL-LEARNING AND MEMORY, MAZE RUNNING STRATEGIES AND CHOLINERGIC MECHANISMS IN 2 INBRED STRAINS OF MICE
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DOI：
10.1016/0166-4328(85)90003-8
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发表时间：
1985-01-01
影响因子：
2.7
通讯作者：
CAPRIOLI, A
中科院分区：
文献类型：
--
作者：
AMMASSARITEULE, M;CAPRIOLI, A
本研究以C57 BL/6和DBA/2两种近交系小鼠为实验动物，研究了径向迷宫任务的获得过程。进行了定量和定性的性能评价，并测量了预测试的活动水平。结果表明，活动和性能之间的显着相关性，因为高活性的C57 BL/6小鼠表现出更好的性能的径向迷宫任务比较不活跃的DBA/2小鼠。此外，对于正确的试验，观察到依赖于菌株的迷宫运行策略：虽然两种菌株显示出大致相同的顺时针和空间策略百分比，但观察到在空间策略中C57 BL/6使用了更多不同的正确解决方案。随后，东莨菪碱管理工作记忆过程的影响进行了评估，在连续和离散的试验。在离散试验中发现每种品系对抗胆碱能治疗的不同反应性，因为仅DBA/2小鼠受损。东莨菪碱的影响进行了讨论，在学习和记忆的实验规则涉及的信息加工的不同模式。
The acquisition process of the radial maze task was studied in two inbred strains of mice, C57BL/6 and DBA/2. A quantitative and qualitative evaluation of performance was performed and the pretest level of activity was measured. The results showed a significant correlation between activity and performance since the highly active C57BL/6 mice exhibited better performance of the radial maze task than the less active DBA/2 mice. Moreover, for correct trials, strain-dependent maze-running strategies were observed: while both strains displayed about the same percentage of clockwise and spatial strategies, it was observed that among the spatial strategies C57BL/6 used a larger number of different correct solutions. Subsequently, the effect of scopolamine administration on working memory processes was assessed in sequential and discrete trials. A different reactivity of each strain to anti-cholinergic treatment was found in discrete trials since only DBA/2 mice were impaired. The effect of scopolamine is discussed in relation to the different models of information processing involved in learning and memorizing the experimental rule.