Cortical superficial siderosis, hematoma volume, and outcomes after intracerebral hemorrhage: a mediation analysis.
Cortical superficial siderosis, hematoma volume, and outcomes after intracerebral hemorrhage: a mediation analysis.
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DOI：
10.3389/fneur.2023.1122744
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发表时间：
2023
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
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先前的研究表明，皮质浅表铁质沉着症（cSS）可增加血肿体积，并预测原发性脑出血（ICH）后的不良结局。我们的目的是确定大血肿量是否是导致cSS结局恶化的重要因素。自发性ICH患者在发作后48小时内接受CT扫描。在7天内使用磁共振成像（MRI）对cSS进行评价。使用改良兰金量表（mRS）评估90天结局。此外，我们使用多变量回归和中介分析研究了cSS、血肿体积和90天结局之间的相关性。在673例ICH患者中[平均（SD）年龄：61（13）岁; 237例女性受试者（35. 2%）;中位（IQR）血肿体积：9. 0（3. 0 - 17. 6）ml]，131例（19. 5%）患有cSS。在多变量回归中，cSS与较大血肿体积之间存在相关性（β = 4.449，95% CI 1.890-7.009，p < 0.001），与血肿位置无关，也与90天mRS较差相关（β = 0.333，95% CI 0.008-0.659，p = 0.045）。此外，中介分析显示，血肿体积是介导cSS对不利90天结局影响的重要因素（介导比例：66.04%，p = 0.01）。大血肿体积是导致轻度至中度ICH患者cSS结局更差的主要原因，cSS与脑叶和非脑叶区域的较大血肿相关。https：//clinicaltrials.gov/ct2/show/NCT04803292，标识符：NCT 04803292。
Previous studies have shown that cortical superficial siderosis (cSS) can increase hematoma volume and predict poor outcomes following primary intracerebral hemorrhage (ICH). We aimed to determine whether a large hematoma volume was the essential factor contributing to worse outcomes of cSS. Patients with spontaneous ICH underwent a CT scan within 48 h after ictus. Evaluation of cSS was performed using magnetic resonance imaging (MRI) within 7 days. The 90-day outcome was assessed using the modified Rankin Scale (mRS). In addition, we investigated the correlation between cSS, hematoma volume, and 90-day outcomes using multivariate regression and mediation analyses. Among the 673 patients with ICH [mean (SD) age, 61 (13) years; 237 female subjects (35.2%); median (IQR) hematoma volume, 9.0 (3.0–17.6) ml], 131 (19.5%) had cSS. There was an association between cSS and larger hematoma volume (β = 4.449, 95% CI 1.890–7.009, p < 0.001) independent of hematoma location and was also related to worse 90-day mRS (β = 0.333, 95% CI 0.008–0.659, p = 0.045) in multivariable regression. In addition, mediation analyses revealed that hematoma volume was an essential factor mediating the effect of cSS on unfavorable 90-day outcomes (proportion mediated:66.04%, p = 0.01). Large hematoma volume was the major charge of directing cSS to worse outcomes in patients with mild to moderate ICH, and cSS was related to a larger hematoma in both lobar and non-lobar areas. https://clinicaltrials.gov/ct2/show/NCT04803292, identifier: NCT04803292.
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影响因子：
8.3
作者：
Saver JL;Filip B;Hamilton S;Yanes A;Craig S;Cho M;Conwit R;Starkman S;FAST-MAG Investigators and Coordinators
通讯作者：
FAST-MAG Investigators and Coordinators
影响因子：
1.7
作者：
Warrier AR;Bhatia R;Garg A;Padma Srivastava MV;Dash D;Tripathi M;Singh MB;Singh V;Vishnubhatla S;Prasad K
通讯作者：
Prasad K
影响因子：
7
作者：
Imai, Kosuke;Keele, Luke;Tingley, Dustin
通讯作者：
Tingley, Dustin
影响因子：
11
作者：
Pasi, Marco;Casolla, Barbara;Cordonnier, Charlotte
通讯作者：
Cordonnier, Charlotte
影响因子：
2.6
作者：
Raseta, M.;Bazarova, A.;Nayak, S.
通讯作者：
Nayak, S.