An MRI based average macaque monkey stereotaxic atlas and space (MNI monkey space)
An MRI based average macaque monkey stereotaxic atlas and space (MNI monkey space)
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DOI：
10.1016/j.neuroimage.2011.01.040
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发表时间：
2011-04-15
期刊：
影响因子：
5.7
通讯作者：
Collins, D. Louis
中科院分区：
文献类型：
--
作者：
Frey, Stephen;Pandya, Deepak N.;Collins, D. Louis
在人脑的研究中，标准的立体定位空间，如蒙特利尔神经学研究所（MNI空间）被广泛用于为功能激活灶和解剖结构的三维定位提供共同的参考，从而能够比较不同研究中获得的结果。在这里，我们提出了一个标准的猕猴大脑MRI模板，提供了一个共同的立体定位参考框架，以本地化的解剖和功能信息在一个有组织的和可靠的方式进行比较，在个别猴子和研究。我们已经使用来自一组25只正常成年猕猴（18只食蟹猴和7只恒河猴）的MRI体积来创建共同的标准猕猴脑以及分别用于这些物种中的每一个的图谱。此外，对数字猕猴体积进行了3D体积分析，并比较了个体大脑与平均图谱之间的大脑结构。此外，我们提供了一种方法，使用简单的基于Web的工具将任何猕猴MRI体积转换为3D中的MNI猴空间坐标。MNI猴空间中的坐标也可以被转换成详细的神经解剖学纸图谱的坐标系（Paxinos等人，2008），使研究人员能够识别和描绘他们的个体猕猴大脑中的皮质和皮质下结构。(C)2011 Elsevier Inc. All rights reserved.
In studies of the human brain, a standard stereotaxic space such as the Montreal Neurological Institute (MNI space) is widely used to provide a common reference for the three-dimensional localization of functional activation foci and anatomical structures, enabling the comparison of results obtained across different studies. Here we present a standard macaque monkey brain MRI template that offers a common stereotaxic reference frame to localize anatomical and functional information in an organized and reliable way for comparison across individual monkeys and studies. We have used MRI volumes from a group of 25 normal adult macaque monkeys (18 cynomolgus and 7 rhesus) to create a common standard macaque monkey brain as well as atlases for each of these species separately. In addition, the digital macaque monkey volume was subjected to 3D volumetric analysis and comparison of brain structures between the individual brains and the average atlas. Furthermore, we provide a means of transforming any macaque MRI volume into MNI monkey space coordinates in 3D using simple web based tools. Coordinates in MNI monkey space can also be transformed into the coordinate system of a detailed neuroanatomical paper atlas (Paxinos et al., 2008), enabling researchers to identify and delineate cortical and subcortical structures in their individual macaque monkey brains. (C) 2011 Elsevier Inc. All rights reserved.