Engineered Heart Repair.

Engineered Heart Repair.
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DOI:
10.1002/cpt.724
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发表时间:
2017-08
影响因子:
6.7
通讯作者:
Zimmermann WH
Zimmermann WH
中科院分区:
医学2区
文献类型:
--
作者:
Fujita B;Zimmermann WH

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迫切需要开发先进的心力衰竭治疗方法。目前的最新技术水平是防止神经体液过度刺激,这未能解决心力衰竭的根本原因,即心肌细胞损失。通过组织工程心肌植入干细胞衍生的心肌细胞正在推进,以实现衰竭心脏的肌肉化。在这里,我们讨论了与组织工程心脏修复的临床转化有关的药理学挑战,重点是工程化心肌(EHM)。
There is a pressing need for the development of advanced heart failure therapeutics. Current state‐of‐the‐art is protection from neurohumoral overstimulation, which fails to address the underlying cause of heart failure, namely loss of cardiomyocytes. Implantation of stem cell‐derived cardiomyocytes via tissue‐engineered myocardium is being advanced to realize the remuscularization of the failing heart. Here, we discuss pharmacological challenges pertaining to the clinical translation of tissue‐engineered heart repair with a focus on engineered heart muscle (EHM).
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