FAMILY HISTORY AND THE RISK OF PROSTATE-CANCER
FAMILY HISTORY AND THE RISK OF PROSTATE-CANCER
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DOI：
10.1002/pros.2990170409
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发表时间：
1990-01-01
期刊：
影响因子：
2.8
通讯作者：
WALSH, PC
中科院分区：
文献类型：
--
作者：
STEINBERG, GD;CARTER, BS;WALSH, PC
进行了一项病例对照研究，以估计有阳性家族史的男性患前列腺癌的相对风险。 对691名前列腺癌患者和640名配偶对照者进行了广泛的癌症家系调查，其中15%的病例和8%的对照者的父亲或兄弟患有前列腺癌（P <0.001）。 有父亲或兄弟患病的男性患前列腺癌的可能性是没有亲属患病的男性的两倍。 此外，随着受影响的家庭成员数量的增加，风险也有增加的趋势，例如有两个或三个一级亲属受影响的男性患前列腺癌的风险增加了5倍和11倍。认识到9-10%的美国男性在一生中会患前列腺癌，有前列腺癌家族史的男性应被告知他们患前列腺癌的风险显著增加，并应接受适当的检查措施。
A case-control study was performed to estimate the relative risk of developing prostate cancer for men with a positive family history. Extensive cancer pedigrees were obtained on 691 men with prostate cancer and 640 spouse controls.Fifteen percent of the cases but only 8% of the controls had a father or brother affected with prostate cancer (P < .001). Men with a father or brother affected were twice as likely to develop prostate cancer as men with no relatives affected. In addition, there was a trend of increasing risk with increasing number of affected family members such that men with two or three first degree relatives affected had a five and 11-fold increased risk of developing prostate cancer.Recognizing that 9-10% of U.S. men will develop prostate cancer in their lifetime, men with a family history of prostate cancer should be advised of their significantly increased prostate cancer risk and should undergo appropriate screening measures for this disease.