Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1
Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1
复制标题
DOI：
10.1016/j.bbrc.2005.10.064
复制
发表时间：
2005-12-16
影响因子：
3.1
通讯作者：
Yoo, YD
中科院分区：
文献类型：
--
作者：
Kim, MJ;Yoo, YA;Yoo, YD
核糖体蛋白质不仅作为翻译器的组成部分，而且还调节细胞增殖和凋亡。先前的研究报道MRPL 41在p53依赖性细胞凋亡中起重要作用。它还表明，MRPL 41通过在不存在p53的情况下稳定p27（Kip 1）来阻止细胞周期。本研究发现，MRPL 41介导p21（WAF 1/CIP 1）介导的G1期阻滞，以响应血清饥饿。通过siRNA介导的MRPL 41表达阻断，使细胞从血清饥饿诱导的G1期阻滞中释放。总之，这些结果表明，MRPL 41通过在生长抑制条件下增加p21（WAF 1/CIP 1）和P27（Kip 1）水平来阻滞细胞周期。(c)2005年爱思唯尔公司All rights reserved.
Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27(Kip1) in the absence of p53. This study found that MRPL41 mediates the p21(WAF1/CIP1)-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and P27(Kip1) levels under the growth inhibitory conditions. (c) 2005 Elsevier Inc. All rights reserved.