Development of an expedient intramolecular Pauson-Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center.
Development of an expedient intramolecular Pauson-Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center.
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DOI：
10.1039/c3cc45170d
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发表时间：
2013-09
影响因子：
4.9
通讯作者：
Lili Shi;Hongjuan Shen;Lichao Fang;Jun Huang;Chuang-Chuang Li-Chuang;Zhen Yang
中科院分区：
文献类型：
--
作者：
Lili Shi;Hongjuan Shen;Lichao Fang;Jun Huang;Chuang-Chuang Li-Chuang;Zhen Yang
通过 Pauson-Khand 反应 (PKR) 作为关键步骤，实现了具有明确的 C1 四级手性中心的反式十氢化萘亚基的立体选择性合成。所开发的化学方法提供了 IMDA 反应的替代方案，该反应已用于合成基于反式十氢化萘的生物活性天然产物。
Stereoselective synthesis of the trans-decalin subunit with a defined C1 quaternary chiral center has been achieved by the Pauson-Khand reaction (PKR) as a key step. The developed chemistry offers an alternative to the IMDA reaction that has been used for the syntheses of trans-decalin based biologically active natural products.