Impact of footrot vaccination and antibiotic therapy on footrot and contagious ovine digital dermatitis
Impact of footrot vaccination and antibiotic therapy on footrot and contagious ovine digital dermatitis
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DOI：
10.1136/vr.100363
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发表时间：
2012-05-01
影响因子：
2.2
通讯作者：
Williams, H. W.
中科院分区：
文献类型：
--
作者：
Duncan, J. S.;Grove-White, D.;Williams, H. W.
在英国，蹄病和传染性绵羊指皮炎（CODD）是绵羊足病的常见原因。本文报道的研究是一项分群随机治疗试验，在英国一个受CODD和蹄病影响的绵羊农场对748只育肥羔羊进行治疗。绵羊被随机分配到两个治疗方案之一。在方案A中，所有绵羊均给予两剂蹄病疫苗（Footvax，MSD），加上靶向抗生素治疗（长效阿莫西林，Betamox LA，Norbrook Pharmaceuticals），以治疗可能与细菌感染相关的足部病变。在方案B中，绵羊仅接受靶向抗生素治疗。绵羊重新检查，并在5周和9周后记录足部病变。与接种组相比，接种组中的新感染率在CODD（18.2%比26.4%，P=0.014）和Footrot（12.55%比27.5%，P
Footrot and contagious ovine digital dermatitis (CODD) are common causes of foot disease of sheep in the UK. The study reported here is a split flock randomised treatment trial undertaken on a group of 748 fattening lambs on a UK sheep farm affected by CODD and footrot. The sheep were randomly assigned to one of two treatment protocols. In protocol A, all sheep were given two doses of footrot vaccine (Footvax, MSD), plus targeted antibiotic therapy (long-acting amoxicillin, Betamox LA, Norbrook Pharmaceuticals) to sheep with foot lesions likely to be associated with a bacterial infection. In protocol B, the sheep only received targeted antibiotic therapy. Sheep were re-examined and foot lesions recorded five and nine weeks later. New infection rates in the footrot vaccinated group were lower compared with the vaccinated group for both CODD (18.2 per cent compared with 26.4 per cent, P=0.014) and footrot (12.55 per cent compared with 27.5 per cent, P