Prevalence of inhaled allergen-specific IgE antibody positivity in the healthy Japanese population
Prevalence of inhaled allergen-specific IgE antibody positivity in the healthy Japanese population
复制标题
日本健康人群吸入过敏原特异性 IgE 抗体阳性的患病率
DOI：
10.1016/j.alit.2021.08.009
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发表时间：
2022
影响因子：
6.8
通讯作者：
Asano Koichiro
中科院分区：
文献类型：
--
作者：
Tanaka Jun;Fukutomi Yuma;Shiraishi Yoshiki;Kitahara Asako;Oguma Tsuyoshi;Hamada Yuto;Watai Kentaro;Nagai Tadashi;Taniguchi Masami;Asano Koichiro
背景资料：测定吸入性过敏原特异性IgE抗体对哮喘、过敏性鼻炎等过敏性疾病的诊断和风险评估具有重要意义。本研究的目的是阐明过敏原致敏的流行率在日本健康人群中使用的血清样本储存在日本红十字会献血，方法：性别分层的血清样本（n= 800），年龄在20-59岁的东京居民随机选择的库存血清中获得的献血在2005年。总IgE抗体和特异性IgE抗体的17个吸入性过敏原的ImmunoCAP方法进行了测量。对至少一种吸入性过敏原具有阳性（≥ 0.35U A/mL）特异性IgE抗体的个体被定义为特应性。来自札幌、大坂、福冈和冲绳20-29岁献血者的库存血清（每种n= 200）也获得了用于测量IgE的六种常见的吸入性过敏原，以评估阳性率的区域差异。在东京的居民中，特应性的患病率为78.0%，在20-29岁的男性中最高（94.0%），随着年龄的增长而下降。特异性IgE抗体检出率以柳杉花粉最高（66.8%），其次为柏树花粉（46.8%）、屋尘螨（38.3%）和蛾类（30.1%）。对柳杉花粉的IgE检测结果表明，D.屋尘螨和蛾鉴定了东京97.6%的特应性受试者。有很大的区域差异的流行率花粉IgE positive.Conclusions：这项研究表明，在日本的健康成年人吸入过敏原特异性IgE抗体阳性的患病率极高。
Background: Measurement of allergen-specific IgE antibodies to inhaled allergens is important for the diagnosis and risk evaluation of allergic diseases such as asthma and allergic rhinitis. This study aimed to elucidate the prevalence of allergen sensitization among the healthy population in Japan using serum samples stocked in the Japanese Red Cross for blood donation.Methods: Age-and gender-stratified serum samples (n= 800) from residents in Tokyo aged 20-59 years were randomly selected from the stocked serum obtained for blood donation in 2005. Total and specific IgE antibodies to 17 inhaled allergens were measured by the ImmunoCAP method. Individuals with positive (≥ 0.35 U A/mL) specific IgE antibodies to at least one inhaled allergen were defined as atopic. Stocked serums from donors aged 20-29 years in Sapporo, Osaka, Fukuoka, and Okinawa (n= 200 each) were also obtained for the measurement of IgE to six common inhaled allergens, to evaluate regional differences in the rate of positivity.Results: Among residents in Tokyo, the prevalence of atopy was 78.0% and highest in men aged 20-29 years (94.0%), which decreased with age. The prevalence of specific IgE antibodies was highest for Japanese cedar pollen (66.8%), followed by cypress pollen (46.8%), Dermatophagoides pteronyssinus (38.3%), and moths (30.1%). Examination of IgE to Japanese cedar pollen, D. pteronyssinus, and moths identified 97.6% of atopic subjects in Tokyo. There were substantial regional differences in the prevalence of pollen IgE positivity.Conclusions: This study demonstrated an extremely high prevalence of positivity in inhaled allergen-specific IgE antibodies among healthy adults in Japan.