Arctium minus crude extract presents antinociceptive effect in a mice acute gout attack model
Arctium minus crude extract presents antinociceptive effect in a mice acute gout attack model
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DOI：
10.1007/s10787-017-0384-6
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发表时间：
2018-04-01
影响因子：
5.8
通讯作者：
Oliveira, Sara Marchesan
中科院分区：
文献类型：
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作者：
Moreira Fischer, Susana Paula;Brusco, Indiara;Oliveira, Sara Marchesan
痛风是一种引发严重炎症反应的疾病，会给患者带来剧烈疼痛和不适。牛蒡（菊科）被称为“牛蒡”，并显示出抗炎、抗伤害、抗风湿疼痛和自由基清除活性。牛蒡属的物种已被用于辅助治疗痛风和其他炎症过程。我们研究了黄芪粗提物的镇痛和抗水肿作用。在成年雄性Swiss小鼠（25-30 g）中通过关节内注射阿托尿酸盐（MSU）晶体诱导的急性痛风发作模型中，采用粗提物法提取A.减去（100 mg/kg，p.o.）减少注射MSU（1.25mg/部位，i.a.）给药后4至8 h。A.在30和100 mg/kg的剂量下，而不是10 mg/kg的剂量下，负种子粗提取物防止机械性异常性疼痛。别嘌呤醇（10 μ g/mL）和A. 10-300 μ g/mL的粗提物在体外抑制黄嘌呤氧化酶活性。助理由于未改变评价的毒理学参数，因此减去种子粗提物未引起不良反应。A.负粗提物可作为痛风疼痛的辅助治疗，支持其传统用法，无不良反应。[图形]。
Gout is a disorder that triggers a severe inflammatory reaction which generates episodes of intense pain and discomfort to the patient. Arctium minus (Hill) Bernh. (Asteraceae) is known as "burdock" and displays anti-inflammatory, antinociceptive, against rheumatic pain and radical-scavenging activities. Species of the genus Arctium have been used in assistant therapy of gout and other inflammatory processes. We investigated the antinociceptive and anti-edematogenic effects of the crude extract of A. minus seeds in an acute gout attack model induced by intra-articular injection of monosodium urate (MSU) crystals in adult male Swiss mice (25-30 g). The crude extract of A. minus (100 mg/kg, p.o.) reduced the mechanical allodynia induced by the injection of MSU (1.25 mg/site, i.a.) from 4 until 8 h after its administration. A. minus seeds crude extract prevented mechanical allodynia at doses of 30 and 100 mg/kg, but not 10 mg/kg. Allopurinol (10 A mu g/mL) and A. minus crude extract (10-300 A mu g/mL) inhibited the xanthine oxidase activity in vitro. The A. minus seeds crude extract did not cause adverse effects since did not change the toxicological parameters evaluated. A. minus crude extract can be used as an assistant therapy of gout pain, supporting its traditional use, without causing adverse effects.[GRAPHICS].