STUDIES ON PATHOGENESIS OF RABIES IN INSECTIVOROUS BATS .3. INFLUENCE OF GRAVID STATE
STUDIES ON PATHOGENESIS OF RABIES IN INSECTIVOROUS BATS .3. INFLUENCE OF GRAVID STATE
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DOI：
10.1093/infdis/112.1.17
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发表时间：
1963-01-01
影响因子：
6.4
通讯作者：
ALLEN, R
中科院分区：
文献类型：
--
作者：
SIMS, RA;SULKIN, SE;ALLEN, R
本文研究了繁殖周期对墨西哥无尾蝙蝠(Tadarida B.miciana)实验性狂犬病感染的影响。设计了一种方法，通过这种方法，可以仅通过胎儿体重来确定每个试验组中的蝙蝠处于大致相同的怀孕阶段，并在这些实验中使用处于生殖周期进展阶段的组。在妊娠期，蝙蝠对狂犬病病毒肌肉接种的敏感性似乎没有明显改变。获得了狂犬病病毒经胎盘传播的证据，并从实验感染的蝙蝠乳腺组织中分离到狂犬病病毒。从实验感染的不同怀孕阶段蝙蝠的棕色脂肪组织中分离出病毒的频率有所不同。讨论了妊娠蝙蝠的生理变化对狂犬病病毒在棕色脂肪组织中增殖的影响。
The present study concerns the influence of the reproductive cycle on experimental rabies infection in the Mexican free-tailed bat (Tadarida b. mexicana). A method was devised whereby it was possible to determine by fetal weight alone that the bats within each experimental group were in approximately the same stage of pregnancy and that groups in progressive stages in the reproductive cycle were used in these experiments. Susceptibility of bats to intramuscular inoculation of rabies virus did not appear to be altered significantly during the gestation period. Evidence of transplacental transmission of rabies virus was obtained, and virus was isolated from mammary gland tissue of experimentally infected bats. Variations were noted in the frequencies of isolation of virus from the brown adipose tissue of experimentally infected bats in different stages of pregnancy. The influence of physiologic alterations occurring in the gravid bat on rabies virus multiplication in brown adipose tissue is discussed.